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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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September-2017 Volume 14 Issue 3

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article Open Access

Doxazosin attenuates renal matrix remodeling mediated by anti-α1-adrenergic receptor antibody in a rat model of diabetes mellitus

  • Authors:
    • Lin‑Shuang Zhao
    • Yan‑Yan Lin
    • Yi Liu
    • Chun‑Yan Xu
    • Ye Liu
    • Wei‑Wei Bai
    • Xue‑Ying Tan
    • De‑Zhong Li
    • Jin‑Ling Xu

  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Wuhan General Hospital of Guangzhou Military Command, Wuhan, Hubei 430070, P.R. China, Medical Experiment Center, Wuhan General Hospital of Guangzhou Military Command, Wuhan, Hubei 430070, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2543-2553
    |
    Published online on: July 21, 2017
       https://doi.org/10.3892/etm.2017.4827
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Abstract

Diabetic nephropathy is a major complication of diabetes mellitus (DM). Recent studies suggest that immunological mechanisms have a key role in the pathogenesis of DM, therefore these mechanisms may be important targets for diabetes therapy. The present study evaluated the effects of anti‑α1‑adrenergic receptor antibody (α1‑R Ab) mediation and doxazosin treatment in a rat model of DM. It was observed that levels of 24‑h urinary protein, serum creatinine and transforming growth factor‑β1 in DM were significantly increased after α1‑R Ab mediation (all P<0.05). In addition, electron microscopy identified severe damage in the renal tissue microstructures of DM rats following α1‑R Ab mediation, while only mild abnormalities were observed in that of healthy rats mediated with α1‑R Ab and of untreated DM rats. No marked abnormalities were observed in the renal tissue of healthy blank controls. Furthermore, in DM rats treated with α1‑R Ab mediation + doxazosin intervention, the expression of TGF‑β1 significantly decreased, and renal functions and renal matrix remodeling were significantly improved, relative to untreated DM controls (P<0.01). These results suggest that α1‑R Ab may be involved in renal matrix remodeling during DM, and that kidney protection during DM may be achieved through treatment with corresponding receptor antagonists.

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Copy and paste a formatted citation
Spandidos Publications style
Zhao LS, Lin YY, Liu Y, Xu CY, Liu Y, Bai WW, Tan XY, Li DZ and Xu JL: Doxazosin attenuates renal matrix remodeling mediated by anti-α1-adrenergic receptor antibody in a rat model of diabetes mellitus. Exp Ther Med 14: 2543-2553, 2017.
APA
Zhao, L., Lin, Y., Liu, Y., Xu, C., Liu, Y., Bai, W. ... Xu, J. (2017). Doxazosin attenuates renal matrix remodeling mediated by anti-α1-adrenergic receptor antibody in a rat model of diabetes mellitus. Experimental and Therapeutic Medicine, 14, 2543-2553. https://doi.org/10.3892/etm.2017.4827
MLA
Zhao, L., Lin, Y., Liu, Y., Xu, C., Liu, Y., Bai, W., Tan, X., Li, D., Xu, J."Doxazosin attenuates renal matrix remodeling mediated by anti-α1-adrenergic receptor antibody in a rat model of diabetes mellitus". Experimental and Therapeutic Medicine 14.3 (2017): 2543-2553.
Chicago
Zhao, L., Lin, Y., Liu, Y., Xu, C., Liu, Y., Bai, W., Tan, X., Li, D., Xu, J."Doxazosin attenuates renal matrix remodeling mediated by anti-α1-adrenergic receptor antibody in a rat model of diabetes mellitus". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2543-2553. https://doi.org/10.3892/etm.2017.4827
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao LS, Lin YY, Liu Y, Xu CY, Liu Y, Bai WW, Tan XY, Li DZ and Xu JL: Doxazosin attenuates renal matrix remodeling mediated by anti-α1-adrenergic receptor antibody in a rat model of diabetes mellitus. Exp Ther Med 14: 2543-2553, 2017.
APA
Zhao, L., Lin, Y., Liu, Y., Xu, C., Liu, Y., Bai, W. ... Xu, J. (2017). Doxazosin attenuates renal matrix remodeling mediated by anti-α1-adrenergic receptor antibody in a rat model of diabetes mellitus. Experimental and Therapeutic Medicine, 14, 2543-2553. https://doi.org/10.3892/etm.2017.4827
MLA
Zhao, L., Lin, Y., Liu, Y., Xu, C., Liu, Y., Bai, W., Tan, X., Li, D., Xu, J."Doxazosin attenuates renal matrix remodeling mediated by anti-α1-adrenergic receptor antibody in a rat model of diabetes mellitus". Experimental and Therapeutic Medicine 14.3 (2017): 2543-2553.
Chicago
Zhao, L., Lin, Y., Liu, Y., Xu, C., Liu, Y., Bai, W., Tan, X., Li, D., Xu, J."Doxazosin attenuates renal matrix remodeling mediated by anti-α1-adrenergic receptor antibody in a rat model of diabetes mellitus". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2543-2553. https://doi.org/10.3892/etm.2017.4827
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