Open Access

Clinical study on the changes of lung-specific proteins: CC16 after lung contusion

  • Authors:
    • Meng-Ni Wen
    • Gang Zhao
    • Jia-Ying Zhang
    • Yong-Hong Zhao
  • View Affiliations

  • Published online on: July 27, 2017     https://doi.org/10.3892/etm.2017.4842
  • Pages: 2733-2736
  • Copyright: © Wen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to examine the clinical value of continuously monitoring serum CC16 levels in diagnosing pulmonary contusion, estimating its severity degree and predicting disease progression. Thirty-one acute trauma patients with lung contusion diagnosed by chest computed tomography (CT) were included, and chest CT was re-examined on day 1, 3 and 7 after injury. Calculating all the contusion volume by the Siemens syngo volume calculation program, complications such as pleural effusion or atelectasis were observed and recorded. ELISA was employed to measure the levels of CC16 in all the patients for seven days, and another 15 serum samples were obtained from healthy volunteers to provide the reference value. Correlation analysis was further conducted for the CC16 levels and pulmonary contusion volume and its variations. Serum concentrations of CC16 in all the lung contusion patients were significantly higher than those in the controls, and reached a peak value on the first day. However, the contusion damage area shown in CT gradually increased with the occurrence of atelectasis and pleural effusion. The maximum volume of lung contusion had a positive correlation to the initial and average concentrations of CC16, and changes in the contusion volume were positively correlated with the initial concentration. The increased concentration of CC16 after lung contusion is an important reference for diagnosis, and may portend the possibility of further progress, while continuously monitoring CC16 serum levels in patients may provide the basis for clinical decision-making.

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September-2017
Volume 14 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wen M, Zhao G, Zhang J and Zhao Y: Clinical study on the changes of lung-specific proteins: CC16 after lung contusion. Exp Ther Med 14: 2733-2736, 2017
APA
Wen, M., Zhao, G., Zhang, J., & Zhao, Y. (2017). Clinical study on the changes of lung-specific proteins: CC16 after lung contusion. Experimental and Therapeutic Medicine, 14, 2733-2736. https://doi.org/10.3892/etm.2017.4842
MLA
Wen, M., Zhao, G., Zhang, J., Zhao, Y."Clinical study on the changes of lung-specific proteins: CC16 after lung contusion". Experimental and Therapeutic Medicine 14.3 (2017): 2733-2736.
Chicago
Wen, M., Zhao, G., Zhang, J., Zhao, Y."Clinical study on the changes of lung-specific proteins: CC16 after lung contusion". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2733-2736. https://doi.org/10.3892/etm.2017.4842