Open Access

Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study

  • Authors:
    • Kwang Ho Yoo
    • Tae‑Rin Kwon
    • Chang Taek Oh
    • Kyeung Chan Ko
    • Yong Hwan No
    • Won Jong Oh
    • Beom Joon Kim
  • View Affiliations

  • Published online on: March 6, 2020     https://doi.org/10.3892/etm.2020.8582
  • Pages: 3282-3288
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Abstract

Penetration of any compound into the body from the outside is prevented primarily by the corneal layer of the epidermis. The only way to circumvent the properties of the corneal layer is to disrupt it. Currently, transdermal systems can currently only deliver drugs that are of low molecular weight. The purpose of the present study was to assess the improvement of the slimming cream's efficacy using a novel fabric, with the aim of developing an improved method for transdermal drug delivery. The current study was conducted on four groups of guinea pigs. The control group was untreated, whereas the test groups were treated with either slimming cream and no fabric, slimming cream with 100% cotton fabric or slimming cream with the novel fabric. Ultrasound and microscopic histological analysis were used to assess animals. The results demonstrated that compared with the other groups, the novel fabric group demonstrated the greatest reductions in fat layer thickness, adipocyte size and number and proliferator‑activated receptor‑γ levels in adipose tissue. Furthermore, the novel fabric also enhanced the transdermal delivery of rhodamine B base and caffeine penetration compared with the control fabric (3.18‑fold). In conclusion, the results of the present study demonstrated that the novel fabric can potentially be used to enhance transdermal drug delivery.

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May 2020
Volume 19 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Yoo, K.H., Kwon, T., Oh, C.T., Ko, K.C., No, Y.H., Oh, W.J., & Kim, B.J. (2020). Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study. Experimental and Therapeutic Medicine, 19, 3282-3288. https://doi.org/10.3892/etm.2020.8582
MLA
Yoo, K. H., Kwon, T., Oh, C. T., Ko, K. C., No, Y. H., Oh, W. J., Kim, B. J."Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study". Experimental and Therapeutic Medicine 19.5 (2020): 3282-3288.
Chicago
Yoo, K. H., Kwon, T., Oh, C. T., Ko, K. C., No, Y. H., Oh, W. J., Kim, B. J."Improvement of a slimming cream's efficacy using a novel fabric as a transdermal drug delivery system: An in vivo and in vitro study". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3282-3288. https://doi.org/10.3892/etm.2020.8582