Open Access

Specific antagonist of receptor for advanced glycation end‑products attenuates delirium‑like behaviours induced by sevoflurane anaesthesia with surgery in aged mice partially by improving damage to the blood‑brain barrier

  • Authors:
    • Ying Deng
    • Jing-Shu Hong
    • Yi-Yun Cao
    • Ning Kang
    • Deng-Yang Han
    • Yi-Tong Li
    • Lei Chen
    • Zheng-Qian Li
    • Rui Zhan
    • Xiang-Yang Guo
    • Ning Yang
    • Cheng-Mei Shi
  • View Affiliations

  • Published online on: May 15, 2023     https://doi.org/10.3892/etm.2023.12016
  • Article Number: 317
  • Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Postoperative delirium (POD), which occurs in hospital up to 1‑week post‑procedure or until discharge, is a common complication, especially in older adult patients. However, the pathogenesis of POD remains unclear. Although damage to blood‑brain barrier (BBB) integrity is involved in the neuropathogenesis of POD, the specific role of the BBB in POD requires further elucidation. Anaesthesia using 2% isoflurane for 4 h results in the upregulation of hippocampal receptor for advanced glycation end‑products (RAGE) expression and β‑amyloid accumulation in aged rats. The present study investigated the role of RAGE in BBB integrity and its mechanisms in POD‑like behaviours. The buried food, open field and Y maze tests were used to evaluate neurobehavioural changes in aged mice following 2.5% sevoflurane anaesthesia administration with exploratory laparotomy. Levels of tight junction proteins were assessed by western blotting. Multiphoton in vivo microscopy was used to observe the ultrastructural changes in the BBB in the hippocampal CA1 region. Anaesthesia with surgery decreased the levels of tight junction proteins occludin and claudin 5, increased matrix metalloproteinases (MMPs) 2 and 9, damaged the ultrastructure of the BBB and induced POD‑like behaviour. FPS‑ZM1, a specific RAGE antagonist, ameliorated POD‑like behaviour induced by anaesthesia and surgery in aged mice. Furthermore, FPS‑ZM1 also restored decreased levels of occludin and claudin 5 as well as increased levels of MMP2 and MMP9. The present findings suggested that RAGE signalling was involved in BBB damage following anaesthesia with surgery. Thus, RAGE has potential as a novel therapeutic intervention for the prevention of POD.

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July-2023
Volume 26 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Deng Y, Hong J, Cao Y, Kang N, Han D, Li Y, Chen L, Li Z, Zhan R, Guo X, Guo X, et al: Specific antagonist of receptor for advanced glycation end‑products attenuates delirium‑like behaviours induced by sevoflurane anaesthesia with surgery in aged mice partially by improving damage to the blood‑brain barrier. Exp Ther Med 26: 317, 2023
APA
Deng, Y., Hong, J., Cao, Y., Kang, N., Han, D., Li, Y. ... Shi, C. (2023). Specific antagonist of receptor for advanced glycation end‑products attenuates delirium‑like behaviours induced by sevoflurane anaesthesia with surgery in aged mice partially by improving damage to the blood‑brain barrier. Experimental and Therapeutic Medicine, 26, 317. https://doi.org/10.3892/etm.2023.12016
MLA
Deng, Y., Hong, J., Cao, Y., Kang, N., Han, D., Li, Y., Chen, L., Li, Z., Zhan, R., Guo, X., Yang, N., Shi, C."Specific antagonist of receptor for advanced glycation end‑products attenuates delirium‑like behaviours induced by sevoflurane anaesthesia with surgery in aged mice partially by improving damage to the blood‑brain barrier". Experimental and Therapeutic Medicine 26.1 (2023): 317.
Chicago
Deng, Y., Hong, J., Cao, Y., Kang, N., Han, D., Li, Y., Chen, L., Li, Z., Zhan, R., Guo, X., Yang, N., Shi, C."Specific antagonist of receptor for advanced glycation end‑products attenuates delirium‑like behaviours induced by sevoflurane anaesthesia with surgery in aged mice partially by improving damage to the blood‑brain barrier". Experimental and Therapeutic Medicine 26, no. 1 (2023): 317. https://doi.org/10.3892/etm.2023.12016