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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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May-2026 Volume 31 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Epigenetics

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Review Open Access

FCER1G: A multifunctional regulator in the immune microenvironment (Review)

  • Authors:
    • Yuyu Zhang
    • Jinglan Wang
    • Wenting He
    • Tao Liu

  • View Affiliations / Copyright

    Affiliations: The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, Gansu 730030, P.R. China, Gansu Provincial Key Laboratory of Environmental Oncology, Lanzhou, Gansu 730030, P.R. China, The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, Gansu 730030, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 146
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    Published online on: March 26, 2026
       https://doi.org/10.3892/etm.2026.13141
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Abstract

The Fc fragment of IgE receptor 1G (FCER1G) gene encodes the Fc receptor common γ chain (FcRγ), a crucial adaptor protein in immune signaling. As the core subunit for multiple immune receptors, including high‑affinity immunoglobulin E receptor, Fc fragment of IgG receptor and C‑type lectin receptors, it regulates both innate and adaptive immune responses through its intracellular immunoreceptor tyrosine‑based activation motif. Downstream effector functions include antibody‑dependent cytotoxicity, phagocytosis and inflammatory cytokine production. Emerging evidence implicates FCER1G in diverse pathological conditions. In inflammatory diseases, epigenetic mechanisms strictly regulate its expression, driving inflammation by influencing immune cell polarization. In the context of cancer, it induces tumor progression by remodeling the immune microenvironment, inducing angiogenesis and enabling platelet‑mediated metastasis. Notably, its prognostic value varies according to tissue origin. Although no current drugs directly target FCER1G, established agents such as aspirin may indirectly modulate its signaling. The present review aimed to summarize the current knowledge on the molecular structure, immune functions and regulatory mechanisms of FCER1G in inflammation and carcinogenesis, establishing a rationale for its potential use as a prognostic biomarker and therapeutic target.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Wang J, He W and Liu T: <em>FCER1G</em>: A multifunctional regulator in the immune microenvironment (Review). Exp Ther Med 31: 146, 2026.
APA
Zhang, Y., Wang, J., He, W., & Liu, T. (2026). <em>FCER1G</em>: A multifunctional regulator in the immune microenvironment (Review). Experimental and Therapeutic Medicine, 31, 146. https://doi.org/10.3892/etm.2026.13141
MLA
Zhang, Y., Wang, J., He, W., Liu, T."<em>FCER1G</em>: A multifunctional regulator in the immune microenvironment (Review)". Experimental and Therapeutic Medicine 31.5 (2026): 146.
Chicago
Zhang, Y., Wang, J., He, W., Liu, T."<em>FCER1G</em>: A multifunctional regulator in the immune microenvironment (Review)". Experimental and Therapeutic Medicine 31, no. 5 (2026): 146. https://doi.org/10.3892/etm.2026.13141
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Wang J, He W and Liu T: <em>FCER1G</em>: A multifunctional regulator in the immune microenvironment (Review). Exp Ther Med 31: 146, 2026.
APA
Zhang, Y., Wang, J., He, W., & Liu, T. (2026). <em>FCER1G</em>: A multifunctional regulator in the immune microenvironment (Review). Experimental and Therapeutic Medicine, 31, 146. https://doi.org/10.3892/etm.2026.13141
MLA
Zhang, Y., Wang, J., He, W., Liu, T."<em>FCER1G</em>: A multifunctional regulator in the immune microenvironment (Review)". Experimental and Therapeutic Medicine 31.5 (2026): 146.
Chicago
Zhang, Y., Wang, J., He, W., Liu, T."<em>FCER1G</em>: A multifunctional regulator in the immune microenvironment (Review)". Experimental and Therapeutic Medicine 31, no. 5 (2026): 146. https://doi.org/10.3892/etm.2026.13141
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