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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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August-2026 Volume 32 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Case Report Open Access

Epithelioid fibrous histiocytoma of eyelid in children: A case report

  • Authors:
    • Zheng Sun
    • Zhaoxia Zhai
    • Yutian Li
    • Peiyan Shi
    • Wei Cheng
    • Jinling Ge
    • Yanfei Li

  • View Affiliations / Copyright

    Affiliations: Department of Strabismus and Pediatric Ophthalmology, Jinan Mingshui Eye Hospital, Jinan, Shandong 250200, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 208
    |
    Published online on: June 5, 2026
       https://doi.org/10.3892/etm.2026.13203
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Abstract

A 7‑year‑old male patient presented to Jinan Mingshui Eye Hospital (Jinan, China) in June 2025 with a 3‑month history of a progressively enlarging mass on the right upper eyelid. The lesion was asymptomatic, with no associated pain, redness or discharge. Physical examination revealed a well‑defined, smooth, yellow‑red, round mass measuring ~6x5x5 mm at the medial canthus of the right upper eyelid, adjacent to the upper lacrimal punctum. Under general anesthesia, the tumor was completely excised in June 2025. Histopathological examination showed squamous epithelium overlying proliferations of small spindle cells, mitotic figures and scattered Touton‑like giant cells. Immunohistochemistry revealed positive staining for CD68, CD163, S‑100, CD1a, CD10 and anaplastic lymphoma kinase (ALK), with a Ki‑67 proliferation index of ~10%. A diagnosis of ALK‑positive epithelioid fibrous histiocytoma (EFH) was established. Postoperative recovery was uneventful, with no recurrence observed during a 6‑month follow‑up period. This case highlights an unusual presentation of EFH in a pediatric eyelid, where a rare tumor that occurred in the eyelid of a 7‑year‑old child was accurately diagnosed through a set of immunohistochemical panels containing tissue cell markers (CD68 and CD163), melanoma cell markers (S‑100), dendritic cell markers (CD1a), mesenchymal cell markers (CD10) and ALK.

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Copy and paste a formatted citation
Spandidos Publications style
Sun Z, Zhai Z, Li Y, Shi P, Cheng W, Ge J and Li Y: Epithelioid fibrous histiocytoma of eyelid in children: A case report. Exp Ther Med 32: 208, 2026.
APA
Sun, Z., Zhai, Z., Li, Y., Shi, P., Cheng, W., Ge, J., & Li, Y. (2026). Epithelioid fibrous histiocytoma of eyelid in children: A case report. Experimental and Therapeutic Medicine, 32, 208. https://doi.org/10.3892/etm.2026.13203
MLA
Sun, Z., Zhai, Z., Li, Y., Shi, P., Cheng, W., Ge, J., Li, Y."Epithelioid fibrous histiocytoma of eyelid in children: A case report". Experimental and Therapeutic Medicine 32.2 (2026): 208.
Chicago
Sun, Z., Zhai, Z., Li, Y., Shi, P., Cheng, W., Ge, J., Li, Y."Epithelioid fibrous histiocytoma of eyelid in children: A case report". Experimental and Therapeutic Medicine 32, no. 2 (2026): 208. https://doi.org/10.3892/etm.2026.13203
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Z, Zhai Z, Li Y, Shi P, Cheng W, Ge J and Li Y: Epithelioid fibrous histiocytoma of eyelid in children: A case report. Exp Ther Med 32: 208, 2026.
APA
Sun, Z., Zhai, Z., Li, Y., Shi, P., Cheng, W., Ge, J., & Li, Y. (2026). Epithelioid fibrous histiocytoma of eyelid in children: A case report. Experimental and Therapeutic Medicine, 32, 208. https://doi.org/10.3892/etm.2026.13203
MLA
Sun, Z., Zhai, Z., Li, Y., Shi, P., Cheng, W., Ge, J., Li, Y."Epithelioid fibrous histiocytoma of eyelid in children: A case report". Experimental and Therapeutic Medicine 32.2 (2026): 208.
Chicago
Sun, Z., Zhai, Z., Li, Y., Shi, P., Cheng, W., Ge, J., Li, Y."Epithelioid fibrous histiocytoma of eyelid in children: A case report". Experimental and Therapeutic Medicine 32, no. 2 (2026): 208. https://doi.org/10.3892/etm.2026.13203
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