Melanomas, from the cell cycle point of view (Review).

Halaban,R; Miglarese,M R; Smicun,Y; Puig,S

doi:10.3892/ijmm.1.2.419

Feb 1998 Volume 1 Issue 2

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Feb 1998 Volume 1 Issue 2

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Article

Melanomas, from the cell cycle point of view (Review).

Authors:
- R Halaban
- M R Miglarese
- Y Smicun
- S Puig
View Affiliations / Copyright

Affiliations: Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520-8059, USA.
Pages: 419-444
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Published online on: February 1, 1998

https://doi.org/10.3892/ijmm.1.2.419
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Abstract

Transformation of melanocytes to metastatic melanoma cells is characterized by unrestricted proliferation under growth-factor-deprived conditions, genetic loss of cyclin dependent kinase (CDK) inhibitors (CKI, e.g. p16INK4A), and aberrant production of autocrine growth factors (e.g. basic fibroblast growth factor). The latter induces increased expression of positive CDK regulators (e.g. cyclin D1) and reduced expression of additional CKIs (e.g. p27KIP1). Combined, these events lead to sustained CDK activity and hyperphosphorylation/inactivation of the retinoblastoma tumor suppressor protein (Rb). The persistent Rb phosphorylation causes the accumulation of E2F and the transcription of its target genes whose products promote cell cycle progression.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Melanomas, from the cell cycle point of view (Review).

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Abstract

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