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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Feb 1998 Volume 1 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Feb 1998 Volume 1 Issue 2

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Article

Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).

  • Authors:
    • M López-Hoyos
    • R Carrió
    • J Merino
    • R Merino
  • View Affiliations / Copyright

    Affiliations: Servicio de Inmunologia, Hospital Universitario Marques de Valdecilla, Spain.
  • Pages: 475-558
    |
    Published online on: February 1, 1998
       https://doi.org/10.3892/ijmm.1.2.475
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Abstract

Cell death is a common event during B cell development. The demise of developing B cells is a regulated process that serves to select cell populations bearing functional receptors and to remove cells that are no longer needed or potentially autoreactive. Bcl-2 and Bcl-XL, two members of the bcl-2 gene family of programmed cell death regulators with anti-apoptotic activity, are expressed in a highly regulated pattern during B cell maturation. Overexpression of Bcl-2 in developing B cells of transgenic mice, in the presence of T cell dependent costimulatory signals, results in the generation of a modified B cell repertoire and in the production of pathogenic autoantibodies. While disregulation of programmed cell death in B cells may cause autoimmune manifestations in mice, the involvement of such alterations in the pathogenesis of autoimmune diseases in humans merits further investigation.

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Copy and paste a formatted citation
Spandidos Publications style
López-Hoyos M, Carrió R, Merino J and Merino R: Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).. Int J Mol Med 1: 475-558, 1998.
APA
López-Hoyos, M., Carrió, R., Merino, J., & Merino, R. (1998). Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).. International Journal of Molecular Medicine, 1, 475-558. https://doi.org/10.3892/ijmm.1.2.475
MLA
López-Hoyos, M., Carrió, R., Merino, J., Merino, R."Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).". International Journal of Molecular Medicine 1.2 (1998): 475-558.
Chicago
López-Hoyos, M., Carrió, R., Merino, J., Merino, R."Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).". International Journal of Molecular Medicine 1, no. 2 (1998): 475-558. https://doi.org/10.3892/ijmm.1.2.475
Copy and paste a formatted citation
x
Spandidos Publications style
López-Hoyos M, Carrió R, Merino J and Merino R: Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).. Int J Mol Med 1: 475-558, 1998.
APA
López-Hoyos, M., Carrió, R., Merino, J., & Merino, R. (1998). Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).. International Journal of Molecular Medicine, 1, 475-558. https://doi.org/10.3892/ijmm.1.2.475
MLA
López-Hoyos, M., Carrió, R., Merino, J., Merino, R."Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).". International Journal of Molecular Medicine 1.2 (1998): 475-558.
Chicago
López-Hoyos, M., Carrió, R., Merino, J., Merino, R."Regulation of B cell apoptosis by Bcl-2 and Bcl-XL and its role in the development of autoimmune diseases (Review).". International Journal of Molecular Medicine 1, no. 2 (1998): 475-558. https://doi.org/10.3892/ijmm.1.2.475
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