A novel autoantibody in paraneoplastic sensory-dominant neuropathy reacts with brain-type creatine kinase.
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- Published online on: March 1, 1998 https://doi.org/10.3892/ijmm.1.3.597
- Pages: 597-1197
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Abstract
We have previously reported on a novel autoantibody in a patient with paraneoplastic sensory-dominant neuropathy. This autoantibody immunostains the rat primary sensory system and reacts with a 47 kDa protein on immunoblotting. Here, we report on the isolation from rat spinal cord of a molecule that is recognized by this autoantibody. By ammonium sulfate cut and gel filtration, affinity and ion exchange chromatographies, the immunoreactive protein was purified to homogeneity and identified as brain-type creatine kinase (B-CK). Our study revealed that the autoantibody of the patient reacted with B-CK in the primary sensory system.
