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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
Jun 1998 Volume 1 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jun 1998 Volume 1 Issue 6

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Article

The genotoxicity and cytotoxicity of dermally-administered cadmium: effects of dermal cadmium administration.

  • Authors:
    • C Fasanya-Odewumi
    • L M Latinwo
    • C O Ikediobi
    • L Gilliard
    • G Sponholtz
    • J Nwoga
    • F Stino
    • N Hamilton
    • G W Erdos

  • View Affiliations / Copyright

    Affiliations: Department of Biology, Division of Environmental Toxicology, College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA.
  • Pages: 1001-1007
    |
    Published online on: June 1, 1998
       https://doi.org/10.3892/ijmm.1.6.1001
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Abstract

Cadmium, unlike zinc, selenium and copper, has no known biological importance, and therefore, it is classified as a carcinogen in humans, as well as in animals. The effect(s) of levels of dermally-administered cadmium on cadmium genotoxicity and cytotoxicity was investigated in Harlan Sprague-Dawley rats for 14, 21, 28, 35 and 42 days at concentrations of 14 and 28 mg/kg/day. Exposure of rats to cadmium via dermal application caused lesions on the skin (hyperkeratosis, acanthosis and scabbing, alopecia and erythema) and tumors in the scrotum. Anatomical changes, such as distention of the stomach, atrophy of kidney and liver and loss of body weight were also observed in these rats. The toxic effects of cadmium on cell ultrastructure were nuclear membrane damage, chromatin condensation, regression of mitochondrial cristae and ultimately cell death. Analyses of the brain, kidney and liver cells of rats exposed to cadmium, clearly showed DNA damage. Of the three organs examined, DNA from kidney cells sustained the most damage followed by DNA in liver cells. There is a positive correlation between Cd dose(s) and duration of exposure and the extent of DNA damage.

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Copy and paste a formatted citation
Spandidos Publications style
Fasanya-Odewumi C, Latinwo L, Ikediobi C, Gilliard L, Sponholtz G, Nwoga J, Stino F, Hamilton N and Erdos G: The genotoxicity and cytotoxicity of dermally-administered cadmium: effects of dermal cadmium administration.. Int J Mol Med 1: 1001-1007, 1998.
APA
Fasanya-Odewumi, C., Latinwo, L., Ikediobi, C., Gilliard, L., Sponholtz, G., Nwoga, J. ... Erdos, G. (1998). The genotoxicity and cytotoxicity of dermally-administered cadmium: effects of dermal cadmium administration.. International Journal of Molecular Medicine, 1, 1001-1007. https://doi.org/10.3892/ijmm.1.6.1001
MLA
Fasanya-Odewumi, C., Latinwo, L., Ikediobi, C., Gilliard, L., Sponholtz, G., Nwoga, J., Stino, F., Hamilton, N., Erdos, G."The genotoxicity and cytotoxicity of dermally-administered cadmium: effects of dermal cadmium administration.". International Journal of Molecular Medicine 1.6 (1998): 1001-1007.
Chicago
Fasanya-Odewumi, C., Latinwo, L., Ikediobi, C., Gilliard, L., Sponholtz, G., Nwoga, J., Stino, F., Hamilton, N., Erdos, G."The genotoxicity and cytotoxicity of dermally-administered cadmium: effects of dermal cadmium administration.". International Journal of Molecular Medicine 1, no. 6 (1998): 1001-1007. https://doi.org/10.3892/ijmm.1.6.1001
Copy and paste a formatted citation
x
Spandidos Publications style
Fasanya-Odewumi C, Latinwo L, Ikediobi C, Gilliard L, Sponholtz G, Nwoga J, Stino F, Hamilton N and Erdos G: The genotoxicity and cytotoxicity of dermally-administered cadmium: effects of dermal cadmium administration.. Int J Mol Med 1: 1001-1007, 1998.
APA
Fasanya-Odewumi, C., Latinwo, L., Ikediobi, C., Gilliard, L., Sponholtz, G., Nwoga, J. ... Erdos, G. (1998). The genotoxicity and cytotoxicity of dermally-administered cadmium: effects of dermal cadmium administration.. International Journal of Molecular Medicine, 1, 1001-1007. https://doi.org/10.3892/ijmm.1.6.1001
MLA
Fasanya-Odewumi, C., Latinwo, L., Ikediobi, C., Gilliard, L., Sponholtz, G., Nwoga, J., Stino, F., Hamilton, N., Erdos, G."The genotoxicity and cytotoxicity of dermally-administered cadmium: effects of dermal cadmium administration.". International Journal of Molecular Medicine 1.6 (1998): 1001-1007.
Chicago
Fasanya-Odewumi, C., Latinwo, L., Ikediobi, C., Gilliard, L., Sponholtz, G., Nwoga, J., Stino, F., Hamilton, N., Erdos, G."The genotoxicity and cytotoxicity of dermally-administered cadmium: effects of dermal cadmium administration.". International Journal of Molecular Medicine 1, no. 6 (1998): 1001-1007. https://doi.org/10.3892/ijmm.1.6.1001
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