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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2002 Volume 10 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2002 Volume 10 Issue 1

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Article

Allelic imbalance in hMLH1 or BRCA2 loci associated with response of cervical and endometrial cancer to radiotherapy

  • Authors:
    • Demetrios A. Arvanitis
    • Emmanouel Angelakis
    • Eugenios E. Koumantakis
    • Demetrios A. Spandidos

  • View Affiliations / Copyright

    Affiliations: Department of Virology, Medical School, University of Crete, Crete, Greece
  • Pages: 55-63
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/ijmm.10.1.55
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Abstract

Effectiveness of radiotherapy is influenced by several genetic properties of the targeted cells. The aim of this study was the identification of prognostic indicators of tumor response to radiation in cervical and endometrial cancer. Using microsatellite DNA analysis, we investigated 31 markers, located on 1p, 2p, 2q, 3p, 9p, 9q, 13q, 17p and 17q for genomic alterations in 37 cervical and 21 endometrial cancer cases, with complete follow-up data. Genetic alterations of the initial tumor genotypes were observed after radiation in 86.5% of cervical and 81.0% of endometrial cases. Reversions to the original normal genotype were observed in 40.5 and 28.6% respectively, predominantly in cured patients rather than in recurred cases. Survival curves by the Kaplan-Meier method showed a worse prognosis for cervical cancer patients whose tumors harbor allelic imbalance (AI) on 3p or 13q, and for endometrial cancer patients whose tumors harbor AI on 13q. Our data suggest a possible association of the hMLH1 or BRCA2 genes, implicated in distinct DNA repair pathways and located on 3p and 13q respectively, with response of cervical and endometrial cancer to radiotherapy. Moreover, microsatellite DNA analysis before and after radiation treatment could be used as a marker of the clinical outcome of patients.

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Copy and paste a formatted citation
Spandidos Publications style
Arvanitis DA, Angelakis E, Koumantakis EE and Spandidos DA: Allelic imbalance in hMLH1 or BRCA2 loci associated with response of cervical and endometrial cancer to radiotherapy. Int J Mol Med 10: 55-63, 2002.
APA
Arvanitis, D.A., Angelakis, E., Koumantakis, E.E., & Spandidos, D.A. (2002). Allelic imbalance in hMLH1 or BRCA2 loci associated with response of cervical and endometrial cancer to radiotherapy. International Journal of Molecular Medicine, 10, 55-63. https://doi.org/10.3892/ijmm.10.1.55
MLA
Arvanitis, D. A., Angelakis, E., Koumantakis, E. E., Spandidos, D. A."Allelic imbalance in hMLH1 or BRCA2 loci associated with response of cervical and endometrial cancer to radiotherapy". International Journal of Molecular Medicine 10.1 (2002): 55-63.
Chicago
Arvanitis, D. A., Angelakis, E., Koumantakis, E. E., Spandidos, D. A."Allelic imbalance in hMLH1 or BRCA2 loci associated with response of cervical and endometrial cancer to radiotherapy". International Journal of Molecular Medicine 10, no. 1 (2002): 55-63. https://doi.org/10.3892/ijmm.10.1.55
Copy and paste a formatted citation
x
Spandidos Publications style
Arvanitis DA, Angelakis E, Koumantakis EE and Spandidos DA: Allelic imbalance in hMLH1 or BRCA2 loci associated with response of cervical and endometrial cancer to radiotherapy. Int J Mol Med 10: 55-63, 2002.
APA
Arvanitis, D.A., Angelakis, E., Koumantakis, E.E., & Spandidos, D.A. (2002). Allelic imbalance in hMLH1 or BRCA2 loci associated with response of cervical and endometrial cancer to radiotherapy. International Journal of Molecular Medicine, 10, 55-63. https://doi.org/10.3892/ijmm.10.1.55
MLA
Arvanitis, D. A., Angelakis, E., Koumantakis, E. E., Spandidos, D. A."Allelic imbalance in hMLH1 or BRCA2 loci associated with response of cervical and endometrial cancer to radiotherapy". International Journal of Molecular Medicine 10.1 (2002): 55-63.
Chicago
Arvanitis, D. A., Angelakis, E., Koumantakis, E. E., Spandidos, D. A."Allelic imbalance in hMLH1 or BRCA2 loci associated with response of cervical and endometrial cancer to radiotherapy". International Journal of Molecular Medicine 10, no. 1 (2002): 55-63. https://doi.org/10.3892/ijmm.10.1.55
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