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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2002 Volume 10 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2002 Volume 10 Issue 1

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Article

Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy

  • Authors:
    • Hongyan Du
    • Boon-Huat Bay
    • Ratha Mahendran
    • Malini Olivo

  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, National University of Singapore, Singapore
  • Pages: 73-76
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/ijmm.10.1.73
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Abstract

Interleukin-8 (Il-8) and IL-10 are cytokines associated with the Epstein Barr Virus (EBV), which is linked with nasopharyngeal cancer (NPC). In the present study, we investigated the endogenous production of IL-8 and IL-10 in vitro by two EBV-positive NPC cell lines, viz., HK1 and CNE-2. IL-8 was expressed by both cell lines although the level of IL-8 was 2-fold higher in supernatant from HK1 cells. Incubation with hypericin, a natural photosensitizer increased IL-8 significantly but only in HK1 cells. Hypericin-based photodynamic therapy (PDT) did not alter the expression of IL-8 levels. Il-10 was not constitutively expressed in either cell line and could not be induced by PDT. It is interesting that PDT which is known to upregulate IL-8 transcription via reactive oxygen species and activate the IL-10 promoter did not alter IL-8 levels in either of the NPC cell lines nor induced the production of IL-10.

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Copy and paste a formatted citation
Spandidos Publications style
Du H, Bay B, Mahendran R and Olivo M: Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy. Int J Mol Med 10: 73-76, 2002.
APA
Du, H., Bay, B., Mahendran, R., & Olivo, M. (2002). Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy. International Journal of Molecular Medicine, 10, 73-76. https://doi.org/10.3892/ijmm.10.1.73
MLA
Du, H., Bay, B., Mahendran, R., Olivo, M."Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy". International Journal of Molecular Medicine 10.1 (2002): 73-76.
Chicago
Du, H., Bay, B., Mahendran, R., Olivo, M."Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy". International Journal of Molecular Medicine 10, no. 1 (2002): 73-76. https://doi.org/10.3892/ijmm.10.1.73
Copy and paste a formatted citation
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Spandidos Publications style
Du H, Bay B, Mahendran R and Olivo M: Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy. Int J Mol Med 10: 73-76, 2002.
APA
Du, H., Bay, B., Mahendran, R., & Olivo, M. (2002). Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy. International Journal of Molecular Medicine, 10, 73-76. https://doi.org/10.3892/ijmm.10.1.73
MLA
Du, H., Bay, B., Mahendran, R., Olivo, M."Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy". International Journal of Molecular Medicine 10.1 (2002): 73-76.
Chicago
Du, H., Bay, B., Mahendran, R., Olivo, M."Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy". International Journal of Molecular Medicine 10, no. 1 (2002): 73-76. https://doi.org/10.3892/ijmm.10.1.73
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