Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy

  • Authors:
    • Hongyan Du
    • Boon-Huat Bay
    • Ratha Mahendran
    • Malini Olivo
  • View Affiliations

  • Published online on: July 1, 2002     https://doi.org/10.3892/ijmm.10.1.73
  • Pages: 73-76
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Abstract

Interleukin-8 (Il-8) and IL-10 are cytokines associated with the Epstein Barr Virus (EBV), which is linked with nasopharyngeal cancer (NPC). In the present study, we investigated the endogenous production of IL-8 and IL-10 in vitro by two EBV-positive NPC cell lines, viz., HK1 and CNE-2. IL-8 was expressed by both cell lines although the level of IL-8 was 2-fold higher in supernatant from HK1 cells. Incubation with hypericin, a natural photosensitizer increased IL-8 significantly but only in HK1 cells. Hypericin-based photodynamic therapy (PDT) did not alter the expression of IL-8 levels. Il-10 was not constitutively expressed in either cell line and could not be induced by PDT. It is interesting that PDT which is known to upregulate IL-8 transcription via reactive oxygen species and activate the IL-10 promoter did not alter IL-8 levels in either of the NPC cell lines nor induced the production of IL-10.

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July 2002
Volume 10 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Du H, Bay B, Mahendran R and Olivo M: Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy. Int J Mol Med 10: 73-76, 2002
APA
Du, H., Bay, B., Mahendran, R., & Olivo, M. (2002). Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy. International Journal of Molecular Medicine, 10, 73-76. https://doi.org/10.3892/ijmm.10.1.73
MLA
Du, H., Bay, B., Mahendran, R., Olivo, M."Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy". International Journal of Molecular Medicine 10.1 (2002): 73-76.
Chicago
Du, H., Bay, B., Mahendran, R., Olivo, M."Endogenous expression of interleukin-8 and interleukin-10 in nasopharyngeal carcinoma cells and the effect of photodynamic therapy". International Journal of Molecular Medicine 10, no. 1 (2002): 73-76. https://doi.org/10.3892/ijmm.10.1.73