Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells

  • Authors:
    • D. Delmas
    • P. Passilly-Degrace
    • B. Jannin
    • M. C. Malki
    • N. Latruffe
  • View Affiliations

  • Published online on: August 1, 2002     https://doi.org/10.3892/ijmm.10.2.193
  • Pages: 193-199
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Resveratrol is a natural polyphenolic compound produced by a number of plants and found in high amount in peanuts, seeds, grapes or berries as source of human nutrition. Epidemiological studies strongly suggest that resveratrol may act as a cancer chemopreventive compound. The mechanism by which resveratrol inhibits cell proliferation was studied in human colorectal tumor SW480 cell line. The results show that resveratrol strongly inhibits cell proliferation at the micromolar range in a time- and dose-dependent manner. Resveratrol appears to block the cell cycle at the transition S↷G2/M since inhibition of [3H]-thymidine incorporation is not observed, while there is an increase of the cell number in S phase. During this inhibition process, resveratrol increases the content of cyclins A and B1 as well as cyclin-dependent kinases Cdk1 and Cdk2. Moreover, resveratrol promotes Cdk1 phosphorylation. In conclusion, resveratrol exerts a strong inhibition of SW480 human colorectal tumor cell proliferation at least by modulating cyclin and cyclin-dependent kinase activities.

Related Articles

Journal Cover

August 2002
Volume 10 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Delmas D, Passilly-Degrace P, Jannin B, Malki MC and Latruffe N: Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells. Int J Mol Med 10: 193-199, 2002
APA
Delmas, D., Passilly-Degrace, P., Jannin, B., Malki, M.C., & Latruffe, N. (2002). Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells. International Journal of Molecular Medicine, 10, 193-199. https://doi.org/10.3892/ijmm.10.2.193
MLA
Delmas, D., Passilly-Degrace, P., Jannin, B., Malki, M. C., Latruffe, N."Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells". International Journal of Molecular Medicine 10.2 (2002): 193-199.
Chicago
Delmas, D., Passilly-Degrace, P., Jannin, B., Malki, M. C., Latruffe, N."Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells". International Journal of Molecular Medicine 10, no. 2 (2002): 193-199. https://doi.org/10.3892/ijmm.10.2.193