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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2002 Volume 10 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2002 Volume 10 Issue 3

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Article

Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines

  • Authors:
    • Jun-Ichi Asaumi
    • Yuzuru Higuchi
    • Jun Murakami
    • Masahiro Kuroda
    • Koichi Shibuya
    • Hironobu Konouchi
    • Miki Hisatomi
    • Hidenobu Matsuzaki
    • Hiroshi Shigehara
    • Shoji Kawasaki
    • Kanji Kishi
    • Yoshio Hiraki

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Radiology, Field of Tumor Biology, Graduate School of Medicine and Dentistry, Okayama University, Okayama 700-8525, Japan. asaumi@md.okayama-u.ac.jp
  • Pages: 287-291
    |
    Published online on: September 1, 2002
       https://doi.org/10.3892/ijmm.10.3.287
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Abstract

Thermoradiosensitivity of 8 cell lines of head and neck squamous cell carcinoma (HO-1-u-1, HSC2, HSC3, HSC4, SAS, KB, Hep2, and Ca9-22) was investigated. The differences of radiosensitivity between the cell line with the highest radiosensitivity and the cell line with the lowest radiosensitivity were 1.7-, 7.7-, and 41-fold at 2, 6 and 8 Gy, respectively. The differences between the cell line with the highest thermosensitivity and the cell line with the lowest thermosensitivity were 2.4-, 6.2- and 34.4-fold at 43°C for 40, 60 and 100 min, and 2.6-, 4.9- and 127-fold at 44°C for 20, 30 and 50 min, respectively. These findings indicated that there were large differences in both radiosensitivity and thermosensitivity among the 8 cell lines. There was a negative relationship between radiosensitivity and thermosensitivity (43°C: r=-0.600, 44°C: r=-0.848) in 7 of 8 cell lines, the exception being the HSC4 cell line, which was resistant to both therapies. Four of the 8 cell lines at 43°C and 5 at 44°C in the radiotherapy combined with thermotherapy showed actual survival rates smaller than the theoretical survival rates. Thus, thermoradiotherapy was deemed effective in the head and neck carcinoma cell lines, although 1 of 8 cell lines was resistant to both radiotherapy and thermotherapy.

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Copy and paste a formatted citation
Spandidos Publications style
Asaumi J, Higuchi Y, Murakami J, Kuroda M, Shibuya K, Konouchi H, Hisatomi M, Matsuzaki H, Shigehara H, Kawasaki S, Kawasaki S, et al: Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines. Int J Mol Med 10: 287-291, 2002.
APA
Asaumi, J., Higuchi, Y., Murakami, J., Kuroda, M., Shibuya, K., Konouchi, H. ... Hiraki, Y. (2002). Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines. International Journal of Molecular Medicine, 10, 287-291. https://doi.org/10.3892/ijmm.10.3.287
MLA
Asaumi, J., Higuchi, Y., Murakami, J., Kuroda, M., Shibuya, K., Konouchi, H., Hisatomi, M., Matsuzaki, H., Shigehara, H., Kawasaki, S., Kishi, K., Hiraki, Y."Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines". International Journal of Molecular Medicine 10.3 (2002): 287-291.
Chicago
Asaumi, J., Higuchi, Y., Murakami, J., Kuroda, M., Shibuya, K., Konouchi, H., Hisatomi, M., Matsuzaki, H., Shigehara, H., Kawasaki, S., Kishi, K., Hiraki, Y."Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines". International Journal of Molecular Medicine 10, no. 3 (2002): 287-291. https://doi.org/10.3892/ijmm.10.3.287
Copy and paste a formatted citation
x
Spandidos Publications style
Asaumi J, Higuchi Y, Murakami J, Kuroda M, Shibuya K, Konouchi H, Hisatomi M, Matsuzaki H, Shigehara H, Kawasaki S, Kawasaki S, et al: Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines. Int J Mol Med 10: 287-291, 2002.
APA
Asaumi, J., Higuchi, Y., Murakami, J., Kuroda, M., Shibuya, K., Konouchi, H. ... Hiraki, Y. (2002). Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines. International Journal of Molecular Medicine, 10, 287-291. https://doi.org/10.3892/ijmm.10.3.287
MLA
Asaumi, J., Higuchi, Y., Murakami, J., Kuroda, M., Shibuya, K., Konouchi, H., Hisatomi, M., Matsuzaki, H., Shigehara, H., Kawasaki, S., Kishi, K., Hiraki, Y."Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines". International Journal of Molecular Medicine 10.3 (2002): 287-291.
Chicago
Asaumi, J., Higuchi, Y., Murakami, J., Kuroda, M., Shibuya, K., Konouchi, H., Hisatomi, M., Matsuzaki, H., Shigehara, H., Kawasaki, S., Kishi, K., Hiraki, Y."Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines". International Journal of Molecular Medicine 10, no. 3 (2002): 287-291. https://doi.org/10.3892/ijmm.10.3.287
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