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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2002 Volume 10 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2002 Volume 10 Issue 5

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Article

Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts

  • Authors:
    • Akira Andoh
    • Kazunori Hata
    • Yoshio Araki
    • Yoshihide Fujiyama
    • Tadao Bamba

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu 520-2192, Japan. andoh@belle.shiga-med.ac.jp
  • Pages: 631-634
    |
    Published online on: November 1, 2002
       https://doi.org/10.3892/ijmm.10.5.631
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Abstract

There is increasing evidence that interleukin (IL)-4 can aid in Th1-type inflammatory responses in chronic colitis models. In this study, we evaluated the effects of IL-4 and/or IL-17 on IL-6 secretion in human colonic myofibroblasts. IL-6 secretion was determined by ELISA and Northern blotting. IL-6 secretion was rapidly induced by either IL-4 or IL-17. IL-17 induced IL-6 mRNA expression within 1 h after stimulation, and reached a maximum at 3 h. IL-6 mRNA induction by IL-4 occurred more rapidly. A maximum induction of IL-6 mRNA by IL-4 was observed at 1 h after stimulation, and this was rapidly decreased. The combination of IL-4 plus IL-17 greatly enhanced IL-6 secretion and mRNA expression. In conclusion, IL-4, in particular IL-4 plus IL-17, induced IL-6 secretion in human colonic myofibroblasts. Th2 immune responses might play an important role in the pathogenesis of gut inflammation.

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Copy and paste a formatted citation
Spandidos Publications style
Andoh A, Hata K, Araki Y, Fujiyama Y and Bamba T: Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts. Int J Mol Med 10: 631-634, 2002.
APA
Andoh, A., Hata, K., Araki, Y., Fujiyama, Y., & Bamba, T. (2002). Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts. International Journal of Molecular Medicine, 10, 631-634. https://doi.org/10.3892/ijmm.10.5.631
MLA
Andoh, A., Hata, K., Araki, Y., Fujiyama, Y., Bamba, T."Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts". International Journal of Molecular Medicine 10.5 (2002): 631-634.
Chicago
Andoh, A., Hata, K., Araki, Y., Fujiyama, Y., Bamba, T."Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts". International Journal of Molecular Medicine 10, no. 5 (2002): 631-634. https://doi.org/10.3892/ijmm.10.5.631
Copy and paste a formatted citation
x
Spandidos Publications style
Andoh A, Hata K, Araki Y, Fujiyama Y and Bamba T: Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts. Int J Mol Med 10: 631-634, 2002.
APA
Andoh, A., Hata, K., Araki, Y., Fujiyama, Y., & Bamba, T. (2002). Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts. International Journal of Molecular Medicine, 10, 631-634. https://doi.org/10.3892/ijmm.10.5.631
MLA
Andoh, A., Hata, K., Araki, Y., Fujiyama, Y., Bamba, T."Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts". International Journal of Molecular Medicine 10.5 (2002): 631-634.
Chicago
Andoh, A., Hata, K., Araki, Y., Fujiyama, Y., Bamba, T."Interleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts". International Journal of Molecular Medicine 10, no. 5 (2002): 631-634. https://doi.org/10.3892/ijmm.10.5.631
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