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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
December 2002 Volume 10 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December 2002 Volume 10 Issue 6

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Article

Inhibition of lung metastasis of B16 melanoma cells exposed to blue light in mice

  • Authors:
    • Masayuki Ohara
    • Yuzo Kawashima
    • Shunichi Kitajima
    • Chizuru Mitsuoka
    • Hiromitsu Watanabe

  • View Affiliations / Copyright

    Affiliations: Otsuka Pharmaceutical Factory, Inc., Muya-cho, Naruto, Tokushima 772-8601, Japan. oharams@otsukakj.co.jp
  • Pages: 701-705
    |
    Published online on: December 1, 2002
       https://doi.org/10.3892/ijmm.10.6.701
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Abstract

The effects of blue light on B16 melanoma cells and on the metastasis of these cells to the lungs were investigated in mice. The exposure of B16 melanoma cells to blue light in two 20-min sessions resulted in marked suppression of cell growth measured at 7 days after exposure. When these cells were harvested, re-inoculated into medium and incubated for a further 7 days, their growth activity returned to almost the same level as that of cultured cells from the non-exposure control group. The melanoma cells harvested after 7 days of incubation were injected intravenously into mice. In the non-exposure group, black nodules developed on the lung surface and the nodules increased in size over time. In the blue-light-exposure group, the development of such black nodules on the lung surface was delayed, and the nodules were smaller. Histopathological examination revealed that blue light suppressed the growth of metastatic tumor cells, and no increase in the number of melanin-containing cells or atypical cells was induced in the metastatic lesions. These results suggest that blue light suppresses the metastasis of B16 melanoma cells.

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Copy and paste a formatted citation
Spandidos Publications style
Ohara M, Kawashima Y, Kitajima S, Mitsuoka C and Watanabe H: Inhibition of lung metastasis of B16 melanoma cells exposed to blue light in mice. Int J Mol Med 10: 701-705, 2002.
APA
Ohara, M., Kawashima, Y., Kitajima, S., Mitsuoka, C., & Watanabe, H. (2002). Inhibition of lung metastasis of B16 melanoma cells exposed to blue light in mice. International Journal of Molecular Medicine, 10, 701-705. https://doi.org/10.3892/ijmm.10.6.701
MLA
Ohara, M., Kawashima, Y., Kitajima, S., Mitsuoka, C., Watanabe, H."Inhibition of lung metastasis of B16 melanoma cells exposed to blue light in mice". International Journal of Molecular Medicine 10.6 (2002): 701-705.
Chicago
Ohara, M., Kawashima, Y., Kitajima, S., Mitsuoka, C., Watanabe, H."Inhibition of lung metastasis of B16 melanoma cells exposed to blue light in mice". International Journal of Molecular Medicine 10, no. 6 (2002): 701-705. https://doi.org/10.3892/ijmm.10.6.701
Copy and paste a formatted citation
x
Spandidos Publications style
Ohara M, Kawashima Y, Kitajima S, Mitsuoka C and Watanabe H: Inhibition of lung metastasis of B16 melanoma cells exposed to blue light in mice. Int J Mol Med 10: 701-705, 2002.
APA
Ohara, M., Kawashima, Y., Kitajima, S., Mitsuoka, C., & Watanabe, H. (2002). Inhibition of lung metastasis of B16 melanoma cells exposed to blue light in mice. International Journal of Molecular Medicine, 10, 701-705. https://doi.org/10.3892/ijmm.10.6.701
MLA
Ohara, M., Kawashima, Y., Kitajima, S., Mitsuoka, C., Watanabe, H."Inhibition of lung metastasis of B16 melanoma cells exposed to blue light in mice". International Journal of Molecular Medicine 10.6 (2002): 701-705.
Chicago
Ohara, M., Kawashima, Y., Kitajima, S., Mitsuoka, C., Watanabe, H."Inhibition of lung metastasis of B16 melanoma cells exposed to blue light in mice". International Journal of Molecular Medicine 10, no. 6 (2002): 701-705. https://doi.org/10.3892/ijmm.10.6.701
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