Cardiomyopathy: Molecular and immunological aspects (Review)

  • Authors:
    • Nobuakira Takeda
  • View Affiliations

  • Published online on: January 1, 2003     https://doi.org/10.3892/ijmm.11.1.13
  • Pages: 13-16
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Abstract

Idiopathic cardiomyopathy is reviewed from molecular standpoint. About a half of all patients with hypertrophic cardiomyopathy show intra-familial occurrence. In familial hypertrophic cardiomyopathy, nine gene abnormalities have been discovered in the sarcomere, i.e. the genes of β cardiac myosin heavy chain, cardiac troponin T, α-tropomyosin, cardiac myosin binding protein-C, essential or regulatory myosin light chain, cardac troponin I, α-cardiac actin, and titin. Sudden death can occur in patients with familial-type hypertrophic cardiomyopathy with abnormalities of the cardiac troponin T or troponin I gene, even if hypertrophy is not marked. Some cases of familial dilated cardiomyopathy show gene abnormalities for cytoskeletal components such as desmin and laminin A/C. Mutations of the δ-sarcoglycan gene have also been discovered in familial or sporadic dilated cardiomyopathy. Mutations in mitochondrial genes have been observed in both hypertrophic and dilated cardiomyopathy. It is postulated that chronic viral myocarditis may sometimes lead to dilated cardiomyopathy, and hepatitis C virus is also thought to be an etiological factor. Immunological abnormalities have also been reported, such as autoantibodies against myosin, β-receptors, ADP/ATP carrier proteins.

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January 2003
Volume 11 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Takeda N: Cardiomyopathy: Molecular and immunological aspects (Review). Int J Mol Med 11: 13-16, 2003.
APA
Takeda, N. (2003). Cardiomyopathy: Molecular and immunological aspects (Review). International Journal of Molecular Medicine, 11, 13-16. https://doi.org/10.3892/ijmm.11.1.13
MLA
Takeda, N."Cardiomyopathy: Molecular and immunological aspects (Review)". International Journal of Molecular Medicine 11.1 (2003): 13-16.
Chicago
Takeda, N."Cardiomyopathy: Molecular and immunological aspects (Review)". International Journal of Molecular Medicine 11, no. 1 (2003): 13-16. https://doi.org/10.3892/ijmm.11.1.13