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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2003 Volume 11 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2003 Volume 11 Issue 1

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Article

The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese

  • Authors:
    • Ching-Tien Peng
    • Jui-Chang Chen
    • Kun-Tu Yeh
    • Yu-Feng Wang
    • Ming-Feng Hou
    • Tai-Ping Lee
    • Mu-Chih Shih
    • Jan-Yi Chang
    • Jan-Gowth Chang

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Medicine and Pediatrics, China Medical College Hospital, Taichung, Taiwan, R.O.C.
  • Pages: 85-89
    |
    Published online on: January 1, 2003
       https://doi.org/10.3892/ijmm.11.1.85
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Abstract

Sulfotransferase (SULT) enzymes play an important role in the detoxification, metabolism and bioactivation of numerous xenobiotics, many dietary and environmental mutagens, drugs, neurotransmitters and hormones. The genes for SULT1A1 and SULT1A2 contain common genetic polymorphisms that are associated with individual variations in the level of enzyme activities as well as variations of biochemical and physical properties. We developed a PCR-RFLP method to analyze the frequencies of SULT1A1 and SULT1A2 alleles among cancerous patients and normal controls in Taiwan. The results showed that SULT1A1*1 and SULT1A2*1 were in positive linkage disequilibrium. Neither SULT1A1*3 nor SULT1A2*3 were found in this study. The frequencies of SULT1A1*2 and SULT1A2*2 for hepatic, colon, lung, oral, gastric, renal and cervical cancerous patients were 3.95, 5.56, 4.92, 3.84, 2.70, 7.41 and 4.50%, respectively. No statistical significance was found for these cancer patients after comparison with normal controls (4.0%) for the allelic frequencies of SULT1A1*2 and SULT1A2*2.

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Copy and paste a formatted citation
Spandidos Publications style
Peng C, Chen J, Yeh K, Wang Y, Hou M, Lee T, Shih M, Chang J and Chang J: The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese. Int J Mol Med 11: 85-89, 2003.
APA
Peng, C., Chen, J., Yeh, K., Wang, Y., Hou, M., Lee, T. ... Chang, J. (2003). The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese. International Journal of Molecular Medicine, 11, 85-89. https://doi.org/10.3892/ijmm.11.1.85
MLA
Peng, C., Chen, J., Yeh, K., Wang, Y., Hou, M., Lee, T., Shih, M., Chang, J., Chang, J."The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese". International Journal of Molecular Medicine 11.1 (2003): 85-89.
Chicago
Peng, C., Chen, J., Yeh, K., Wang, Y., Hou, M., Lee, T., Shih, M., Chang, J., Chang, J."The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese". International Journal of Molecular Medicine 11, no. 1 (2003): 85-89. https://doi.org/10.3892/ijmm.11.1.85
Copy and paste a formatted citation
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Spandidos Publications style
Peng C, Chen J, Yeh K, Wang Y, Hou M, Lee T, Shih M, Chang J and Chang J: The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese. Int J Mol Med 11: 85-89, 2003.
APA
Peng, C., Chen, J., Yeh, K., Wang, Y., Hou, M., Lee, T. ... Chang, J. (2003). The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese. International Journal of Molecular Medicine, 11, 85-89. https://doi.org/10.3892/ijmm.11.1.85
MLA
Peng, C., Chen, J., Yeh, K., Wang, Y., Hou, M., Lee, T., Shih, M., Chang, J., Chang, J."The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese". International Journal of Molecular Medicine 11.1 (2003): 85-89.
Chicago
Peng, C., Chen, J., Yeh, K., Wang, Y., Hou, M., Lee, T., Shih, M., Chang, J., Chang, J."The relationship among the polymorphisms of SULT1A1, 1A2 and different types of cancers in Taiwanese". International Journal of Molecular Medicine 11, no. 1 (2003): 85-89. https://doi.org/10.3892/ijmm.11.1.85
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