Association of an interleukin-1β gene polymorphism at position -511 with Alzheimer's disease

  • Authors:
    • Christian Ehl
    • Heike Kölsch
    • Ursula Ptok
    • Frank Jessen
    • Sandra Schmitz
    • Christine Frahnert
    • Ralf Schlösser
    • Marie Luise Rao
    • Wolfgang Maier
    • Reinhard Heun
  • View Affiliations

  • Published online on: February 1, 2003     https://doi.org/10.3892/ijmm.11.2.235
  • Pages: 235-238
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Inflammation is thought to promote neuronal cell death in Alzheimer's disease (AD). The proinflammatory interleukin-1 is a main component in inflammatory pathways and is overexpressed in the brain of AD patients. Investigation of different polymorphisms in the interleukin-1 genes (IL-1α -889, IL-1β -511, IL-1β +3953) revealed associations between specific alleles and AD in that they increased the risk or modified the age at onset of AD. However, there are controversial findings from other studies which revealed no significant associations between these polymorphisms and AD; thus further evaluation of the association of IL-1 gene polymorphisms with AD and their role in pathogenesis is needed. In this study we examined the distribution of the IL-1β -511 alleles in AD patients and a control sample of healthy individuals. An additional control population of non-demented depressive inpatients was recruited to exclude a confounding bias. The cerebrospinal fluid (CSF) levels of Aβ42 in AD patients were investigated to assess the influence of IL-1β -511 genotypes. We found no significant association of the IL-1β -511 polymorphism with AD, suggesting that the IL-1β -511 polymorphism is no risk factor for AD. However, we found the Aβ42 CSF levels to be lower in carriers of the IL-1β CC-genotype compared to carriers of the T-allele. Even though IL-1β -511 polymorphism did not influence the risk of AD it might have a pathophysiological influence on the disease process.

Related Articles

Journal Cover

February 2003
Volume 11 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ehl C, Kölsch H, Ptok U, Jessen F, Schmitz S, Frahnert C, Schlösser R, Rao ML, Maier W, Heun R, Heun R, et al: Association of an interleukin-1β gene polymorphism at position -511 with Alzheimer's disease. Int J Mol Med 11: 235-238, 2003.
APA
Ehl, C., Kölsch, H., Ptok, U., Jessen, F., Schmitz, S., Frahnert, C. ... Heun, R. (2003). Association of an interleukin-1β gene polymorphism at position -511 with Alzheimer's disease. International Journal of Molecular Medicine, 11, 235-238. https://doi.org/10.3892/ijmm.11.2.235
MLA
Ehl, C., Kölsch, H., Ptok, U., Jessen, F., Schmitz, S., Frahnert, C., Schlösser, R., Rao, M. L., Maier, W., Heun, R."Association of an interleukin-1β gene polymorphism at position -511 with Alzheimer's disease". International Journal of Molecular Medicine 11.2 (2003): 235-238.
Chicago
Ehl, C., Kölsch, H., Ptok, U., Jessen, F., Schmitz, S., Frahnert, C., Schlösser, R., Rao, M. L., Maier, W., Heun, R."Association of an interleukin-1β gene polymorphism at position -511 with Alzheimer's disease". International Journal of Molecular Medicine 11, no. 2 (2003): 235-238. https://doi.org/10.3892/ijmm.11.2.235