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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
June 2003 Volume 11 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2003 Volume 11 Issue 6

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Article

Manumycin inhibits cell proliferation and the Ras signal transduction pathway in human hepatocellular carcinoma cells

  • Authors:
    • Jun-Min Zhou
    • Xiao-Feng Zhu
    • Qi-Chao Pan
    • Duan-Fang Liao
    • Zhi-Ming Li
    • Zong-Chao Liu

  • View Affiliations / Copyright

    Affiliations: Cancer Institute, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China
  • Pages: 767-771
    |
    Published online on: June 1, 2003
       https://doi.org/10.3892/ijmm.11.6.767
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Abstract

Manumycin was reported to have inhibitory effect on farnesyltransferase by competing with the farnesyl pyrophosphate substrate. It exhibited different antiproliferative activity in human hepatocellular carcinoma HepG2 cells, primary cultured human cardiac muscle cells and human liver cells (CLC). HepG2 cells overexpressing ras gene were more sensitive to manumycin than the other cells. The difference might be related to Ras protein levels in these cell lines. Manumycin reduced the amount of functional ras localized at the cytoplasmic membrane, resulting in blocked C-raf-1 assocation with Ras. Manumycin inhibited ERK1/2 phosphorylation in HepG2 cells without reduced expression of ERK1/2 protein. The levels of protein MKP-1 were significantly up-regulated. Our study also demonstrated that manumycin inhibited p85/PI3K and Akt phosphorylation without reduced expression of p85/PI3K and Akt, and interfered with the association of p85/PI3K and Ras. These findings indicated that manumycin interfered with Ras membrane localization, shut down the downstream pathways of Ras and inhibited cell proliferation in HepG2 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Zhu X, Pan Q, Liao D, Li Z and Liu Z: Manumycin inhibits cell proliferation and the Ras signal transduction pathway in human hepatocellular carcinoma cells. Int J Mol Med 11: 767-771, 2003.
APA
Zhou, J., Zhu, X., Pan, Q., Liao, D., Li, Z., & Liu, Z. (2003). Manumycin inhibits cell proliferation and the Ras signal transduction pathway in human hepatocellular carcinoma cells. International Journal of Molecular Medicine, 11, 767-771. https://doi.org/10.3892/ijmm.11.6.767
MLA
Zhou, J., Zhu, X., Pan, Q., Liao, D., Li, Z., Liu, Z."Manumycin inhibits cell proliferation and the Ras signal transduction pathway in human hepatocellular carcinoma cells". International Journal of Molecular Medicine 11.6 (2003): 767-771.
Chicago
Zhou, J., Zhu, X., Pan, Q., Liao, D., Li, Z., Liu, Z."Manumycin inhibits cell proliferation and the Ras signal transduction pathway in human hepatocellular carcinoma cells". International Journal of Molecular Medicine 11, no. 6 (2003): 767-771. https://doi.org/10.3892/ijmm.11.6.767
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Zhu X, Pan Q, Liao D, Li Z and Liu Z: Manumycin inhibits cell proliferation and the Ras signal transduction pathway in human hepatocellular carcinoma cells. Int J Mol Med 11: 767-771, 2003.
APA
Zhou, J., Zhu, X., Pan, Q., Liao, D., Li, Z., & Liu, Z. (2003). Manumycin inhibits cell proliferation and the Ras signal transduction pathway in human hepatocellular carcinoma cells. International Journal of Molecular Medicine, 11, 767-771. https://doi.org/10.3892/ijmm.11.6.767
MLA
Zhou, J., Zhu, X., Pan, Q., Liao, D., Li, Z., Liu, Z."Manumycin inhibits cell proliferation and the Ras signal transduction pathway in human hepatocellular carcinoma cells". International Journal of Molecular Medicine 11.6 (2003): 767-771.
Chicago
Zhou, J., Zhu, X., Pan, Q., Liao, D., Li, Z., Liu, Z."Manumycin inhibits cell proliferation and the Ras signal transduction pathway in human hepatocellular carcinoma cells". International Journal of Molecular Medicine 11, no. 6 (2003): 767-771. https://doi.org/10.3892/ijmm.11.6.767
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