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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2003 Volume 12 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2003 Volume 12 Issue 1

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Article

The transmembrane domain of vesicular stomatitis virus glycoprotein suffices to anchor HIV-1 envelope gp120 expressed by a recombinant vaccinia virus

  • Authors:
    • Y. Jin
    • S. E. Wright

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, University of Miami, FL 33136, USA
  • Pages: 11-16
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/ijmm.12.1.11
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Abstract

The shedding of HIV-1 glycoprotein gp120 results from the proteolytic cleavage of its precursor gp160 into gp120 and an anchoring gp41, to which gp120 is non-covalently attached. This report is directed toward the anchorage of gp120 expressed by three recombinant vaccinia virus (rvv): vPE16 expresses wild-type gp160; vvE13 the gp120-vesicular stomatitis virus G transmembrane and cytoplasmic tail (VSVGTMCT) fusion protein; and vvE14 the gp120 with 52 amino acids (aa) from the vector. In order to convert gp120 into an integral membrane protein, a gp120- VSVGTMCT chimerical gene fragment has been constructed and expressed in mammalian cells. This gp120 fusion protein expressed by an rvv, vvE13, has been shown to elicit better immunogenicity and protection against a gp160-expressing tumor cell line than the full-length envelope (env) glycoprotein gp160 in mice. The results show that gp120-VSVGTMCT expressed by vvE13 is not shed because it is membrane associated. The hydrophobic fragment of vesicular stomatitis virus G (VSVG) furnishes an anchor of the chimeric protein just as it does in the native VSVG.

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Copy and paste a formatted citation
Spandidos Publications style
Jin Y and Wright SE: The transmembrane domain of vesicular stomatitis virus glycoprotein suffices to anchor HIV-1 envelope gp120 expressed by a recombinant vaccinia virus. Int J Mol Med 12: 11-16, 2003.
APA
Jin, Y., & Wright, S.E. (2003). The transmembrane domain of vesicular stomatitis virus glycoprotein suffices to anchor HIV-1 envelope gp120 expressed by a recombinant vaccinia virus. International Journal of Molecular Medicine, 12, 11-16. https://doi.org/10.3892/ijmm.12.1.11
MLA
Jin, Y., Wright, S. E."The transmembrane domain of vesicular stomatitis virus glycoprotein suffices to anchor HIV-1 envelope gp120 expressed by a recombinant vaccinia virus". International Journal of Molecular Medicine 12.1 (2003): 11-16.
Chicago
Jin, Y., Wright, S. E."The transmembrane domain of vesicular stomatitis virus glycoprotein suffices to anchor HIV-1 envelope gp120 expressed by a recombinant vaccinia virus". International Journal of Molecular Medicine 12, no. 1 (2003): 11-16. https://doi.org/10.3892/ijmm.12.1.11
Copy and paste a formatted citation
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Spandidos Publications style
Jin Y and Wright SE: The transmembrane domain of vesicular stomatitis virus glycoprotein suffices to anchor HIV-1 envelope gp120 expressed by a recombinant vaccinia virus. Int J Mol Med 12: 11-16, 2003.
APA
Jin, Y., & Wright, S.E. (2003). The transmembrane domain of vesicular stomatitis virus glycoprotein suffices to anchor HIV-1 envelope gp120 expressed by a recombinant vaccinia virus. International Journal of Molecular Medicine, 12, 11-16. https://doi.org/10.3892/ijmm.12.1.11
MLA
Jin, Y., Wright, S. E."The transmembrane domain of vesicular stomatitis virus glycoprotein suffices to anchor HIV-1 envelope gp120 expressed by a recombinant vaccinia virus". International Journal of Molecular Medicine 12.1 (2003): 11-16.
Chicago
Jin, Y., Wright, S. E."The transmembrane domain of vesicular stomatitis virus glycoprotein suffices to anchor HIV-1 envelope gp120 expressed by a recombinant vaccinia virus". International Journal of Molecular Medicine 12, no. 1 (2003): 11-16. https://doi.org/10.3892/ijmm.12.1.11
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