Prostaglandin E2 synthesis in human monocyte-derived dendritic cells

  • Authors:
    • Johannes Norgauer
    • Yvonne Ibig
    • Doris Gmeiner
    • Yared Herouy
    • Bernd L. Fiebich
  • View Affiliations

  • Published online on: July 1, 2003     https://doi.org/10.3892/ijmm.12.1.83
  • Pages: 83-86
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Abstract

Prostaglandin E2 (PGE2), which is generated by the enzymatic activity of cyclooxygenase-1 and -2 (COX-1/2), plays a central role in the maturation process of dendritic cells (DC). Since regulation of COX-1/2 expression in human DC is only partially understood, we addressed the expression and activity of COX-1/2 in these cells. Here we show that lipopolysaccharide (lps) induces COX-2 mRNA and protein synthesis as well as the release of PGE2 in human interleukin-4 and granulocyte/macrophage colony-stimulating factor-differentiated monocyte-derived DC cultivated in the presence of 1% human plasma. Moreover, we found that lps induces p38 stress-activated protein kinase (p38) in these cells and inhibitors of p38 blocked lps-induced COX-2 expression and activity. Our data indicate that during lps-induced maturation p38 regulates COX-2 expression and PGE2 synthesis in DC.

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July 2003
Volume 12 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Norgauer J, Ibig Y, Gmeiner D, Herouy Y and Fiebich BL: Prostaglandin E2 synthesis in human monocyte-derived dendritic cells. Int J Mol Med 12: 83-86, 2003
APA
Norgauer, J., Ibig, Y., Gmeiner, D., Herouy, Y., & Fiebich, B.L. (2003). Prostaglandin E2 synthesis in human monocyte-derived dendritic cells. International Journal of Molecular Medicine, 12, 83-86. https://doi.org/10.3892/ijmm.12.1.83
MLA
Norgauer, J., Ibig, Y., Gmeiner, D., Herouy, Y., Fiebich, B. L."Prostaglandin E2 synthesis in human monocyte-derived dendritic cells". International Journal of Molecular Medicine 12.1 (2003): 83-86.
Chicago
Norgauer, J., Ibig, Y., Gmeiner, D., Herouy, Y., Fiebich, B. L."Prostaglandin E2 synthesis in human monocyte-derived dendritic cells". International Journal of Molecular Medicine 12, no. 1 (2003): 83-86. https://doi.org/10.3892/ijmm.12.1.83