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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2003 Volume 12 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2003 Volume 12 Issue 1

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Article

Cloning and structural characterization of the human histone deacetylase 6 gene

  • Authors:
    • Susanne Voelter-Mahlknecht
    • Ulrich Mahlknecht

  • View Affiliations / Copyright

    Affiliations: Department of Hematology/Oncology, University of Frankfurt Medical Center, D-60590 Frankfurt, Germany
  • Pages: 87-93
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    Published online on: July 1, 2003
       https://doi.org/10.3892/ijmm.12.1.87
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Abstract

Histone deacetylases (HDACs) play a central role in the modification of chromatin structure and thus in the regulation of transcription and cellular differentiation. Based on structural and functional similarities, mammalian histone deacetylases may be grouped into three categories, class I HDACs, which are homologs of the yeast histone deacetylase RPD3, class II HDACs, which share a significant degree of homology with the yeast histone deacetylase HDA1 and class III HDACs which are closely related to the yeast SIR2 protein. We have isolated and characterized the human HDAC6 genomic sequence, which spans a region of 21,923 bp and which has one single genomic locus. Determination of the exon-intron splice junctions established that HDAC6 is encoded by 28 exons ranging in size from 41 bp (exon 5) to 677 bp (exon 24). Characterization of the 5' flanking genomic region, which precedes the HDAC6 open reading frame, revealed a TATA- and CCAAT-boxless promoter that contains a 1 kb CpG island. The 3,648 bp human HDAC6 mRNA encodes a 1,215 aa protein with a predictive molecular weight of 131.4 kDa. Fluorescence in situ hybridization analysis localized the human HDAC6 gene to the subband border of chromosome Xp11.22-23, a region which is characterized by frequent gains and losses of chromosomal material in several types of cancer and neurological disorders.

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Copy and paste a formatted citation
Spandidos Publications style
Voelter-Mahlknecht S and Mahlknecht U: Cloning and structural characterization of the human histone deacetylase 6 gene. Int J Mol Med 12: 87-93, 2003.
APA
Voelter-Mahlknecht, S., & Mahlknecht, U. (2003). Cloning and structural characterization of the human histone deacetylase 6 gene. International Journal of Molecular Medicine, 12, 87-93. https://doi.org/10.3892/ijmm.12.1.87
MLA
Voelter-Mahlknecht, S., Mahlknecht, U."Cloning and structural characterization of the human histone deacetylase 6 gene". International Journal of Molecular Medicine 12.1 (2003): 87-93.
Chicago
Voelter-Mahlknecht, S., Mahlknecht, U."Cloning and structural characterization of the human histone deacetylase 6 gene". International Journal of Molecular Medicine 12, no. 1 (2003): 87-93. https://doi.org/10.3892/ijmm.12.1.87
Copy and paste a formatted citation
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Spandidos Publications style
Voelter-Mahlknecht S and Mahlknecht U: Cloning and structural characterization of the human histone deacetylase 6 gene. Int J Mol Med 12: 87-93, 2003.
APA
Voelter-Mahlknecht, S., & Mahlknecht, U. (2003). Cloning and structural characterization of the human histone deacetylase 6 gene. International Journal of Molecular Medicine, 12, 87-93. https://doi.org/10.3892/ijmm.12.1.87
MLA
Voelter-Mahlknecht, S., Mahlknecht, U."Cloning and structural characterization of the human histone deacetylase 6 gene". International Journal of Molecular Medicine 12.1 (2003): 87-93.
Chicago
Voelter-Mahlknecht, S., Mahlknecht, U."Cloning and structural characterization of the human histone deacetylase 6 gene". International Journal of Molecular Medicine 12, no. 1 (2003): 87-93. https://doi.org/10.3892/ijmm.12.1.87
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