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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2004 Volume 13 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2004 Volume 13 Issue 3

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Article

Genetic and environmental factors associated with plasma paraoxonase activity in healthy Chinese

  • Authors:
    • Xiaoling Wang
    • Jianfeng Huang
    • Zhongjie Fan
    • Shaoyong Su
    • Jiangong Zhao
    • Yan Shen
    • Boqin Qiang
    • Dongfeng Gu

  • View Affiliations / Copyright

    Affiliations: Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China
  • Pages: 445-450
    |
    Published online on: March 1, 2004
       https://doi.org/10.3892/ijmm.13.3.445
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Abstract

To characterize factors associated with plasma paraoxonase 1 (PON1) activity in healthy Chinese Han population, we carried out the present study, not only taking into account the total set of frequent polymorphisms present in PON1 gene in the Chinese Han population, but also some environmental factors. The -107T/C polymorphism as well as drinking and smoking were independently associated with plasma PON1 activity, determined by rates of phenylacetate hydrolysis. The -107T/C polymorphism had the predominant effect and accounted for 16% of the observed variability in plasma PON1 activity. Alcohol consumption can modulate the effects of cigarette smoking on PON1 activity, and smoking only decreases PON1 activity in non-drinkers. The increase of PON1 activity by drinking or the inhibition of PON1 activity by smoking varies according to PON1 -107T/C genotypes, and the associations were only observed in -107T allele carriers. The results illustrate the complexity of polymorphism-phenotype associations. The observed interactions constitute concrete examples of gene-environment and environment-environment interactions.

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Huang J, Fan Z, Su S, Zhao J, Shen Y, Qiang B and Gu D: Genetic and environmental factors associated with plasma paraoxonase activity in healthy Chinese. Int J Mol Med 13: 445-450, 2004.
APA
Wang, X., Huang, J., Fan, Z., Su, S., Zhao, J., Shen, Y. ... Gu, D. (2004). Genetic and environmental factors associated with plasma paraoxonase activity in healthy Chinese. International Journal of Molecular Medicine, 13, 445-450. https://doi.org/10.3892/ijmm.13.3.445
MLA
Wang, X., Huang, J., Fan, Z., Su, S., Zhao, J., Shen, Y., Qiang, B., Gu, D."Genetic and environmental factors associated with plasma paraoxonase activity in healthy Chinese". International Journal of Molecular Medicine 13.3 (2004): 445-450.
Chicago
Wang, X., Huang, J., Fan, Z., Su, S., Zhao, J., Shen, Y., Qiang, B., Gu, D."Genetic and environmental factors associated with plasma paraoxonase activity in healthy Chinese". International Journal of Molecular Medicine 13, no. 3 (2004): 445-450. https://doi.org/10.3892/ijmm.13.3.445
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Huang J, Fan Z, Su S, Zhao J, Shen Y, Qiang B and Gu D: Genetic and environmental factors associated with plasma paraoxonase activity in healthy Chinese. Int J Mol Med 13: 445-450, 2004.
APA
Wang, X., Huang, J., Fan, Z., Su, S., Zhao, J., Shen, Y. ... Gu, D. (2004). Genetic and environmental factors associated with plasma paraoxonase activity in healthy Chinese. International Journal of Molecular Medicine, 13, 445-450. https://doi.org/10.3892/ijmm.13.3.445
MLA
Wang, X., Huang, J., Fan, Z., Su, S., Zhao, J., Shen, Y., Qiang, B., Gu, D."Genetic and environmental factors associated with plasma paraoxonase activity in healthy Chinese". International Journal of Molecular Medicine 13.3 (2004): 445-450.
Chicago
Wang, X., Huang, J., Fan, Z., Su, S., Zhao, J., Shen, Y., Qiang, B., Gu, D."Genetic and environmental factors associated with plasma paraoxonase activity in healthy Chinese". International Journal of Molecular Medicine 13, no. 3 (2004): 445-450. https://doi.org/10.3892/ijmm.13.3.445
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