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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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March 2004 Volume 13 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2004 Volume 13 Issue 3

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Article

Inhibition of the O-glycan elongation limits MUC1 incorporation to cell membrane of human endometrial carcinoma cells

  • Authors:
    • Halina Porowska
    • Anna Paszkiewicz-Gadek
    • Tomasz Anchim
    • Slawomir Wolczynski
    • Andrzej Gindzienski

  • View Affiliations / Copyright

    Affiliations: Department of Medical Chemistry, Medical Academy, 15-222 Bialystok, Poland. zachemog@amb.edu.pl
  • Pages: 459-464
    |
    Published online on: March 1, 2004
       https://doi.org/10.3892/ijmm.13.3.459
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Abstract

We have studied how benzyl-N-acetyl-α-D-galactosaminide, O-glycosylation inhibitor, affects the polymorphism and shedding of membrane-bound MUC1 mucin, and change in adhesive properties of cancer cells. In endometrial adenocarcinoma cells (Ishikawa line), high molecular weight MUC1 mucin was shed from cellular membrane and could be detected in culture medium 24 h after [14C]threonine labelling. Short-time (2 days) exposure of these cells to benzyl-N-acetyl-α-D-galactosaminide was associated with a reduction in sialic acid level and increase in T antigen content in cellular MUC1 mucin. These changes could be inverted after removal of the inhibitor. A longer, 6-day action of the inhibitor induced a decrease in sialic acid and T antigen levels in cellular MUC1 mucin. Benzyl-N-acetyl-α-D-galactosaminide treatment caused the occurrence of a few incompletely glycosylated glycoforms of MUC1 in cells, but not in culture medium. Adhesion of endometrial cells to ECM compounds (type I collagen) was increased by benzyl-N-acetyl-α-D-galactosaminide treatment, indicating that glycosylation of extracellular domain of MUC1 can modulate adhesive properties of cells.

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Copy and paste a formatted citation
Spandidos Publications style
Porowska H, Paszkiewicz-Gadek A, Anchim T, Wolczynski S and Gindzienski A: Inhibition of the O-glycan elongation limits MUC1 incorporation to cell membrane of human endometrial carcinoma cells. Int J Mol Med 13: 459-464, 2004.
APA
Porowska, H., Paszkiewicz-Gadek, A., Anchim, T., Wolczynski, S., & Gindzienski, A. (2004). Inhibition of the O-glycan elongation limits MUC1 incorporation to cell membrane of human endometrial carcinoma cells. International Journal of Molecular Medicine, 13, 459-464. https://doi.org/10.3892/ijmm.13.3.459
MLA
Porowska, H., Paszkiewicz-Gadek, A., Anchim, T., Wolczynski, S., Gindzienski, A."Inhibition of the O-glycan elongation limits MUC1 incorporation to cell membrane of human endometrial carcinoma cells". International Journal of Molecular Medicine 13.3 (2004): 459-464.
Chicago
Porowska, H., Paszkiewicz-Gadek, A., Anchim, T., Wolczynski, S., Gindzienski, A."Inhibition of the O-glycan elongation limits MUC1 incorporation to cell membrane of human endometrial carcinoma cells". International Journal of Molecular Medicine 13, no. 3 (2004): 459-464. https://doi.org/10.3892/ijmm.13.3.459
Copy and paste a formatted citation
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Spandidos Publications style
Porowska H, Paszkiewicz-Gadek A, Anchim T, Wolczynski S and Gindzienski A: Inhibition of the O-glycan elongation limits MUC1 incorporation to cell membrane of human endometrial carcinoma cells. Int J Mol Med 13: 459-464, 2004.
APA
Porowska, H., Paszkiewicz-Gadek, A., Anchim, T., Wolczynski, S., & Gindzienski, A. (2004). Inhibition of the O-glycan elongation limits MUC1 incorporation to cell membrane of human endometrial carcinoma cells. International Journal of Molecular Medicine, 13, 459-464. https://doi.org/10.3892/ijmm.13.3.459
MLA
Porowska, H., Paszkiewicz-Gadek, A., Anchim, T., Wolczynski, S., Gindzienski, A."Inhibition of the O-glycan elongation limits MUC1 incorporation to cell membrane of human endometrial carcinoma cells". International Journal of Molecular Medicine 13.3 (2004): 459-464.
Chicago
Porowska, H., Paszkiewicz-Gadek, A., Anchim, T., Wolczynski, S., Gindzienski, A."Inhibition of the O-glycan elongation limits MUC1 incorporation to cell membrane of human endometrial carcinoma cells". International Journal of Molecular Medicine 13, no. 3 (2004): 459-464. https://doi.org/10.3892/ijmm.13.3.459
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