The peptide nucleic acids, efficient tools for molecular diagnosis (Review)

  • Authors:
    • Franck Pellestor
    • Petra Paulasova
  • View Affiliations

  • Published online on: April 1, 2004     https://doi.org/10.3892/ijmm.13.4.521
  • Pages: 521-525
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Abstract

Peptide nucleic acids (PNAs) are synthetic analogs of DNA that hybridize with complementary DNAs or RNAs with high affinity and specificity, essentially because of an uncharged and flexible polyamide backbone. Originally conceived as ligand for the recognition of double stranded DNA, the unique physico-chemical properties of PNAs have led to the development of a variety of research and diagnostic assays. Initially used as antisense and antigene reagents, the more recent applications of PNA have involved their use as molecular hybridization probes. Thus, sensitive and robust PNA-dependent methods have been designed for developing anti-cancer drugs, modulating PCR reactions, detecting genomic mutation or labelling chromosomes in situ.

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April 2004
Volume 13 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Pellestor F and Paulasova P: The peptide nucleic acids, efficient tools for molecular diagnosis (Review). Int J Mol Med 13: 521-525, 2004.
APA
Pellestor, F., & Paulasova, P. (2004). The peptide nucleic acids, efficient tools for molecular diagnosis (Review). International Journal of Molecular Medicine, 13, 521-525. https://doi.org/10.3892/ijmm.13.4.521
MLA
Pellestor, F., Paulasova, P."The peptide nucleic acids, efficient tools for molecular diagnosis (Review)". International Journal of Molecular Medicine 13.4 (2004): 521-525.
Chicago
Pellestor, F., Paulasova, P."The peptide nucleic acids, efficient tools for molecular diagnosis (Review)". International Journal of Molecular Medicine 13, no. 4 (2004): 521-525. https://doi.org/10.3892/ijmm.13.4.521