Apoptosis in prostate cancer: Progressive and therapeutic implications (Review)

  • Authors:
    • Gangduo Wang
    • Eddie Reed
    • Qingdi Q. Li
  • View Affiliations

  • Published online on: October 1, 2004     https://doi.org/10.3892/ijmm.14.1.23
  • Pages: 23-34
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Abstract

Prostate cancer is the most common non-cutaneous malignancy in American men and the second greatest cause of cancer-related death. Development of effective therapeutic modalities for the treatment of this cancer relies heavily on understanding the molecular alterations that result in the initiation and progression of the tumorigenic process. Increasing evidence indicates that impaired ability to undergo apoptosis plays an important role in the evolution from androgen-dependent to androgen-independent prostate cancer. In this review, we address recent progress toward the central objectives of understanding the molecular events that contribute to prostate cancer progression. We focus on some key regulatory molecules, including the pro-apoptotic regulators p53, PTEN, caspases and Par-4, and the anti-apoptotic molecules Bcl-2, NF-κB and Akt, to discuss their roles in prostate cancer progression and their therapeutic implications in human prostate carcinoma.

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October 2004
Volume 14 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Wang G, Reed E and Li QQ: Apoptosis in prostate cancer: Progressive and therapeutic implications (Review). Int J Mol Med 14: 23-34, 2004
APA
Wang, G., Reed, E., & Li, Q.Q. (2004). Apoptosis in prostate cancer: Progressive and therapeutic implications (Review). International Journal of Molecular Medicine, 14, 23-34. https://doi.org/10.3892/ijmm.14.1.23
MLA
Wang, G., Reed, E., Li, Q. Q."Apoptosis in prostate cancer: Progressive and therapeutic implications (Review)". International Journal of Molecular Medicine 14.1 (2004): 23-34.
Chicago
Wang, G., Reed, E., Li, Q. Q."Apoptosis in prostate cancer: Progressive and therapeutic implications (Review)". International Journal of Molecular Medicine 14, no. 1 (2004): 23-34. https://doi.org/10.3892/ijmm.14.1.23