Expression of CXCL16 in human rectal cancer

Wågsäter,Dick; Hugander,Anders; Dimberg,Jan

doi:10.3892/ijmm.14.1.65

October 2004 Volume 14 Issue 1

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October 2004 Volume 14 Issue 1

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Article

Expression of CXCL16 in human rectal cancer

Authors:
- Dick Wågsäter
- Anders Hugander
- Jan Dimberg
View Affiliations / Copyright

Affiliations: Division of Biomedicine, Department of Caring Sciences, University of Örebro, SE-701 82 Örebro, Sweden. dick.wagsater@ivo.oru.se
Pages: 65-69
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Published online on: October 1, 2004

https://doi.org/10.3892/ijmm.14.1.65
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Abstract

Local immunoregulation mediated by infiltration of inflammatory cells into colorectal adenocarcinomas is important for tumour progression. Tumour-associated macrophages and T cells are predominant components of chemokine-guided infiltrate of most colorectal tumours. CXCL16 is a newly discovered CXC chemokine expressed by antigen presenting cells attracting Th1, Tc and NK T cells. In this study, which is the first report on expression of the chemokine CXCL16 in human rectal cancer, CXCL16 gene and protein expression were analysed in cancer and normal adjacent tissue. Immunohistochemistry revealed CXCL16 expression in macrophages in normal tissue. The CXCL16 was found to a very limited extent in tumour-associated macrophages. Western blot analysis showed a suppression of CXCL16 protein in rectal cancer compared to non-cancer tissue in 83% of the patients (n=23, P=0.003). However, with real-time PCR mRNA was not down-regulated in the cancer compared to normal tissue, which may depend on regulated factor(s) at the level of translation and/or post-translation. The results may reflect one of the immunological mechanisms underlying carcinogenesis.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of CXCL16 in human rectal cancer

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Abstract

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