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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2004 Volume 14 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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December 2004 Volume 14 Issue 6

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Article

2-O-methylisohemigossylic acid lactone, a sesquiterpene, isolated from roots of mokumen (Gossampinus malabarica) induces cell death and morphological change indicative of apoptotic chromatin condensation in human promyelotic leukemia HL-60 cells

  • Authors:
    • Hiroshige Hibasami
    • Kazumi Saitoh
    • Hirotaka Katsuzaki
    • Kunio Imai
    • Yue Aratanechemuge
    • Takashi Komiya

  • View Affiliations / Copyright

    Affiliations: Faculty of Medicine, Mie University, Mie 514-0001, Japan
  • Pages: 1029-1033
    |
    Published online on: December 1, 2004
       https://doi.org/10.3892/ijmm.14.6.1029
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Abstract

2-O-methylisohemigossylic acid lactone, a sesquiterpene, was purified from roots of mokumen (Gossampinus malabarica) and identified by Mass, and 1H- and 13-NMR. This sesquiterpene displayed strong growth inhibitory effect against human promyelotic leukemia HL-60 cells. Apoptotic morphological change of the nucleus, including chromatin condensation was induced in the HL-60 cells treated with the sesquiterpene. The fragmentation of DNA by the sesquiterpene to oligonucleosomal-sized fragments, a characteristic of apoptosis, was observed to be dose- and time-dependent in the HL-60 cells. Inhibitors of caspases suppressed the DNA fragmentation induced by the sesquiterpene. These findings suggest that growth inhibition by the sesquiterpene of HL-60 cells results from the induction of apoptosis by the sesqui-terpene, and that caspase cascade is involved in the induction of apoptosis by the compound in the HL-60 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Hibasami H, Saitoh K, Katsuzaki H, Imai K, Aratanechemuge Y and Komiya T: 2-O-methylisohemigossylic acid lactone, a sesquiterpene, isolated from roots of mokumen (Gossampinus malabarica) induces cell death and morphological change indicative of apoptotic chromatin condensation in human promyelotic leukemia HL-60 cells. Int J Mol Med 14: 1029-1033, 2004.
APA
Hibasami, H., Saitoh, K., Katsuzaki, H., Imai, K., Aratanechemuge, Y., & Komiya, T. (2004). 2-O-methylisohemigossylic acid lactone, a sesquiterpene, isolated from roots of mokumen (Gossampinus malabarica) induces cell death and morphological change indicative of apoptotic chromatin condensation in human promyelotic leukemia HL-60 cells. International Journal of Molecular Medicine, 14, 1029-1033. https://doi.org/10.3892/ijmm.14.6.1029
MLA
Hibasami, H., Saitoh, K., Katsuzaki, H., Imai, K., Aratanechemuge, Y., Komiya, T."2-O-methylisohemigossylic acid lactone, a sesquiterpene, isolated from roots of mokumen (Gossampinus malabarica) induces cell death and morphological change indicative of apoptotic chromatin condensation in human promyelotic leukemia HL-60 cells". International Journal of Molecular Medicine 14.6 (2004): 1029-1033.
Chicago
Hibasami, H., Saitoh, K., Katsuzaki, H., Imai, K., Aratanechemuge, Y., Komiya, T."2-O-methylisohemigossylic acid lactone, a sesquiterpene, isolated from roots of mokumen (Gossampinus malabarica) induces cell death and morphological change indicative of apoptotic chromatin condensation in human promyelotic leukemia HL-60 cells". International Journal of Molecular Medicine 14, no. 6 (2004): 1029-1033. https://doi.org/10.3892/ijmm.14.6.1029
Copy and paste a formatted citation
x
Spandidos Publications style
Hibasami H, Saitoh K, Katsuzaki H, Imai K, Aratanechemuge Y and Komiya T: 2-O-methylisohemigossylic acid lactone, a sesquiterpene, isolated from roots of mokumen (Gossampinus malabarica) induces cell death and morphological change indicative of apoptotic chromatin condensation in human promyelotic leukemia HL-60 cells. Int J Mol Med 14: 1029-1033, 2004.
APA
Hibasami, H., Saitoh, K., Katsuzaki, H., Imai, K., Aratanechemuge, Y., & Komiya, T. (2004). 2-O-methylisohemigossylic acid lactone, a sesquiterpene, isolated from roots of mokumen (Gossampinus malabarica) induces cell death and morphological change indicative of apoptotic chromatin condensation in human promyelotic leukemia HL-60 cells. International Journal of Molecular Medicine, 14, 1029-1033. https://doi.org/10.3892/ijmm.14.6.1029
MLA
Hibasami, H., Saitoh, K., Katsuzaki, H., Imai, K., Aratanechemuge, Y., Komiya, T."2-O-methylisohemigossylic acid lactone, a sesquiterpene, isolated from roots of mokumen (Gossampinus malabarica) induces cell death and morphological change indicative of apoptotic chromatin condensation in human promyelotic leukemia HL-60 cells". International Journal of Molecular Medicine 14.6 (2004): 1029-1033.
Chicago
Hibasami, H., Saitoh, K., Katsuzaki, H., Imai, K., Aratanechemuge, Y., Komiya, T."2-O-methylisohemigossylic acid lactone, a sesquiterpene, isolated from roots of mokumen (Gossampinus malabarica) induces cell death and morphological change indicative of apoptotic chromatin condensation in human promyelotic leukemia HL-60 cells". International Journal of Molecular Medicine 14, no. 6 (2004): 1029-1033. https://doi.org/10.3892/ijmm.14.6.1029
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