Truncated hepatitis C virus core protein encoded in hepatocellular carcinomas

Yamaguchi,Rin; Momosaki,Seiya; Gao,Guang; Hsia,Chu Chieh; Kojiro,Masamichi; Scudamore,Charles; Tabor,Edward

doi:10.3892/ijmm.14.6.1097

December 2004 Volume 14 Issue 6

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December 2004 Volume 14 Issue 6

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Article

Truncated hepatitis C virus core protein encoded in hepatocellular carcinomas

Authors:
- Rin Yamaguchi
- Seiya Momosaki
- Guang Gao
- Chu Chieh Hsia
- Masamichi Kojiro
- Charles Scudamore
- Edward Tabor
View Affiliations / Copyright

Affiliations: Division of Emerging and Transfusion Transmitted Diseases, Food and Drug Administration, Bethesda, MD, USA
Pages: 1097-1100
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Published online on: December 1, 2004

https://doi.org/10.3892/ijmm.14.6.1097
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Abstract

Studies have suggested that a truncated form of the hepatitis C virus (HCV) core protein can enter hepatocyte nuclei and might play a role in HCV-associated hepato-carcinogenesis. In the present study, the HCV core gene from hepatocellular carcinomas (HCC) and/or adjacent non-tumorous liver tissues from eight patients was amplified by nested RT-PCR and sequenced. Mutations in the HCV core gene that would encode a truncated core protein were found in 4 of the 8 patients. Since truncated core proteins have been shown to be capable of entry into the hepatocyte nucleus (unlike HCV itself, which is an exclusively cytoplasmic virus), the detection of mutated sequences encoding them in these four HCC patients suggests that these mutations may have played a role in the development of these HCCs.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Truncated hepatitis C virus core protein encoded in hepatocellular carcinomas

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Abstract

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