STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy

  • Authors:
    • Kazunori Yukawa
    • Masanori Kishino
    • Mikako Goda
    • Xiang-Ming Liang
    • Akihiko Kimura
    • Tetsuji Tanaka
    • Tao Bai
    • Kyoko Owada-Makabe
    • Yuji Tsubota
    • Takashi Ueyama
    • Masakazu Ichinose
    • Masanobu Maeda
    • Kiyoshi Takeda
    • Shizuo Akira
  • View Affiliations

  • Published online on: February 1, 2005     https://doi.org/10.3892/ijmm.15.2.225
  • Pages: 225-230
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Abstract

To elucidate the contribution of signal transducer and activator of transcription (STAT) 6 to the pathophysiology of chronic renal injury, STAT6-/- mice were subjected to unilateral ureteral ligation together with wild-type control mice. STAT6-/- kidneys had more apoptotic cells and a greater influx of F4/80-positive cells than wild-type kidneys following ureteral obstruction. There was a much larger α-smooth muscle actin-positive area in STAT6-/- kidneys than in wild-type kidneys after ureteral ligation. However, renal fibrosis, as quantified by Masson-Trichrome staining, was not significantly exaggerated in STAT6-/- kidneys compared with wild-type kidneys. The accumulation of collagen I was significantly less in STAT6-/- kidneys than in wild-type kidneys. These observations indicate that the STAT6 signal transduction pathway exerts a protective role on renal cell apoptosis in chronic obstructive uropathy. Our findings also suggest that the STAT6 pathway may have a promotive effect on renal fibrosis by activating collagen synthesis following ureteral obstruction.

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February 2005
Volume 15 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yukawa K, Kishino M, Goda M, Liang X, Kimura A, Tanaka T, Bai T, Owada-Makabe K, Tsubota Y, Ueyama T, Ueyama T, et al: STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy. Int J Mol Med 15: 225-230, 2005.
APA
Yukawa, K., Kishino, M., Goda, M., Liang, X., Kimura, A., Tanaka, T. ... Akira, S. (2005). STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy. International Journal of Molecular Medicine, 15, 225-230. https://doi.org/10.3892/ijmm.15.2.225
MLA
Yukawa, K., Kishino, M., Goda, M., Liang, X., Kimura, A., Tanaka, T., Bai, T., Owada-Makabe, K., Tsubota, Y., Ueyama, T., Ichinose, M., Maeda, M., Takeda, K., Akira, S."STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy". International Journal of Molecular Medicine 15.2 (2005): 225-230.
Chicago
Yukawa, K., Kishino, M., Goda, M., Liang, X., Kimura, A., Tanaka, T., Bai, T., Owada-Makabe, K., Tsubota, Y., Ueyama, T., Ichinose, M., Maeda, M., Takeda, K., Akira, S."STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy". International Journal of Molecular Medicine 15, no. 2 (2005): 225-230. https://doi.org/10.3892/ijmm.15.2.225