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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2005 Volume 15 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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February 2005 Volume 15 Issue 2

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Article

Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells

  • Authors:
    • Tsunehiko Yoshida
    • Takashi Iwamoto
    • Koichi Adachi
    • Takashi Yokota
    • Yozo Miyake
    • Michinari Hamaguchi

  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Nagoya University School of Medicine, Showa-ku, Nagoya 466-8550, Japan
  • Pages: 269-275
    |
    Published online on: February 1, 2005
       https://doi.org/10.3892/ijmm.15.2.269
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Abstract

M1 mouse myeloid leukemia cells exhibit growth arrest and differentiation to monocytes/macrophages in response to leukemia inhibitory factor (LIF) stimulation. Although recent studies have demonstrated that STAT3 plays a central role in this process, it is unknown whether STAT3 activation alone is sufficient. To address this issue, we have established M1/STAT3ER cells, where STAT3 is selectively activated by 4-hydroxytamoxifen (4HT). 4HT stimulation did not have any effect on growth and morphology of M1/ STAT3ER cells, and did not induce the down-regulation of mRNA of c-myc and c-myb, which is necessary for M1 cell differentiation. On the other hand, mRNA of jun-B, IRF1 and p19 was increased by 4HT. DNA precipitation assay indicated that both stimulation of LIF and 4HT similarly activated STAT3ER. Introduction of a constitutive active MAP kinase kinase (MEK1) into M1/STAT3ER cells did not induce differentiation either. Together, our present data suggest that signaling other than the activation of STAT3 and MEK1 may be necessary for M1 cell-growth arrest and differentiation, while a set of early genes of LIF are induced by only STAT3 activation.

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Copy and paste a formatted citation
Spandidos Publications style
Yoshida T, Iwamoto T, Adachi K, Yokota T, Miyake Y and Hamaguchi M: Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells. Int J Mol Med 15: 269-275, 2005.
APA
Yoshida, T., Iwamoto, T., Adachi, K., Yokota, T., Miyake, Y., & Hamaguchi, M. (2005). Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells. International Journal of Molecular Medicine, 15, 269-275. https://doi.org/10.3892/ijmm.15.2.269
MLA
Yoshida, T., Iwamoto, T., Adachi, K., Yokota, T., Miyake, Y., Hamaguchi, M."Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells". International Journal of Molecular Medicine 15.2 (2005): 269-275.
Chicago
Yoshida, T., Iwamoto, T., Adachi, K., Yokota, T., Miyake, Y., Hamaguchi, M."Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells". International Journal of Molecular Medicine 15, no. 2 (2005): 269-275. https://doi.org/10.3892/ijmm.15.2.269
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshida T, Iwamoto T, Adachi K, Yokota T, Miyake Y and Hamaguchi M: Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells. Int J Mol Med 15: 269-275, 2005.
APA
Yoshida, T., Iwamoto, T., Adachi, K., Yokota, T., Miyake, Y., & Hamaguchi, M. (2005). Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells. International Journal of Molecular Medicine, 15, 269-275. https://doi.org/10.3892/ijmm.15.2.269
MLA
Yoshida, T., Iwamoto, T., Adachi, K., Yokota, T., Miyake, Y., Hamaguchi, M."Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells". International Journal of Molecular Medicine 15.2 (2005): 269-275.
Chicago
Yoshida, T., Iwamoto, T., Adachi, K., Yokota, T., Miyake, Y., Hamaguchi, M."Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells". International Journal of Molecular Medicine 15, no. 2 (2005): 269-275. https://doi.org/10.3892/ijmm.15.2.269
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