Up-regulation of β-catenin in external auditory canal cholesteatoma

  • Authors:
    • Ramin Naim
    • Ray C. Chang
    • Clemens Anders
    • Haneen Sadick
    • Frank Riedel
    • Christiane Bayerl
    • Gregor Bran
    • Karl Hormann
  • View Affiliations

  • Published online on: May 1, 2005     https://doi.org/10.3892/ijmm.15.5.801
  • Pages: 801-804
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The external auditory canal cholesteatoma (EACC) is a rare disease with hyperproliferation and destructive growth in the adjacent structures. Down-regulation of β-catenin (key component of the zonula adherens) is a pivotal factor for loose tissue integrity and invasiveness. Transforming growth factor β1 (TGF-β1) was reported to decrease β-catenin in mammary epithelium. We investigated the abrogation of TGF-β1 and β-catenin expression in EACC culture cells. Cultured EACC-specimens were incubated with 6 µmol TGF-β1 antisense. After 48 h, expression of β-catenin was determined by means of immunohistochemistry. The cells showed an increased mural reactivity to β-catenin, and intracellular reactivity was unchanged. The untreated cells showed a loss of β-catenin expression at the membranes. The predominant membranous location after treatment with TGF-β1 antisense suggests increased tendency of the cells for tissue formation and strong cell-cell adhesion rather than migratory and invasive character, and thus TGF-β1 antisense application is a useful therapeutical strategy.

Related Articles

Journal Cover

May 2005
Volume 15 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Naim R, Chang RC, Anders C, Sadick H, Riedel F, Bayerl C, Bran G and Hormann K: Up-regulation of β-catenin in external auditory canal cholesteatoma. Int J Mol Med 15: 801-804, 2005
APA
Naim, R., Chang, R.C., Anders, C., Sadick, H., Riedel, F., Bayerl, C. ... Hormann, K. (2005). Up-regulation of β-catenin in external auditory canal cholesteatoma. International Journal of Molecular Medicine, 15, 801-804. https://doi.org/10.3892/ijmm.15.5.801
MLA
Naim, R., Chang, R. C., Anders, C., Sadick, H., Riedel, F., Bayerl, C., Bran, G., Hormann, K."Up-regulation of β-catenin in external auditory canal cholesteatoma". International Journal of Molecular Medicine 15.5 (2005): 801-804.
Chicago
Naim, R., Chang, R. C., Anders, C., Sadick, H., Riedel, F., Bayerl, C., Bran, G., Hormann, K."Up-regulation of β-catenin in external auditory canal cholesteatoma". International Journal of Molecular Medicine 15, no. 5 (2005): 801-804. https://doi.org/10.3892/ijmm.15.5.801