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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2005 Volume 15 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease

  • Authors:
    • El-Nasir Lalani
    • Richard Poulsom
    • Gordon Stamp
    • Franz Fogt
    • Peter Thomas
    • Amin A. Nanji

  • View Affiliations / Copyright

    Affiliations: Departments of Histopathology, Imperial College School of Medicine, Hammersmith Campus, London, UK
  • Pages: 811-817
    |
    Published online on: May 1, 2005
       https://doi.org/10.3892/ijmm.15.5.811
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Abstract

Expression of hepatocyte growth factor (HGF) and its receptor, c-met is up-regulated in various forms of liver injury. This study evaluated the relationship between HGF and c-met expression and pathological changes in experimental alcoholic liver disease. Rats (5 per group) were fed ethanol and a diet containing saturated fat corn oil or fish oil by intragastric infusion. Dextrose isocalorically replaced ethanol in controls. In a second set of experiments, Kupffer cells, endothelial cells and hepatocytes were isolated from rats in each group. Pathological evaluation and analysis of HGF and c-met expression were performed in liver and the different cell types. Increased expression of HGF and c-met expression was detected in the liver of rats showing necroinflammatory changes. The Kupffer and endothelial cells were primarily responsible for the increase in HGF, c-met expression was seen only in hepatocytes. Thus, up-regulation of HGF and c-met occurred in the presence of the necrosis and inflammation suggesting that HGF may be acting to protect against liver injury or accelerate the regenerative process.

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Copy and paste a formatted citation
Spandidos Publications style
Lalani E, Poulsom R, Stamp G, Fogt F, Thomas P and Nanji AA: Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease. Int J Mol Med 15: 811-817, 2005.
APA
Lalani, E., Poulsom, R., Stamp, G., Fogt, F., Thomas, P., & Nanji, A.A. (2005). Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease. International Journal of Molecular Medicine, 15, 811-817. https://doi.org/10.3892/ijmm.15.5.811
MLA
Lalani, E., Poulsom, R., Stamp, G., Fogt, F., Thomas, P., Nanji, A. A." Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease". International Journal of Molecular Medicine 15.5 (2005): 811-817.
Chicago
Lalani, E., Poulsom, R., Stamp, G., Fogt, F., Thomas, P., Nanji, A. A." Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease". International Journal of Molecular Medicine 15, no. 5 (2005): 811-817. https://doi.org/10.3892/ijmm.15.5.811
Copy and paste a formatted citation
x
Spandidos Publications style
Lalani E, Poulsom R, Stamp G, Fogt F, Thomas P and Nanji AA: Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease. Int J Mol Med 15: 811-817, 2005.
APA
Lalani, E., Poulsom, R., Stamp, G., Fogt, F., Thomas, P., & Nanji, A.A. (2005). Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease. International Journal of Molecular Medicine, 15, 811-817. https://doi.org/10.3892/ijmm.15.5.811
MLA
Lalani, E., Poulsom, R., Stamp, G., Fogt, F., Thomas, P., Nanji, A. A." Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease". International Journal of Molecular Medicine 15.5 (2005): 811-817.
Chicago
Lalani, E., Poulsom, R., Stamp, G., Fogt, F., Thomas, P., Nanji, A. A." Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease". International Journal of Molecular Medicine 15, no. 5 (2005): 811-817. https://doi.org/10.3892/ijmm.15.5.811
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