Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats

  • Authors:
    • Satoshi Uchiyama
    • Masayoshi Yamaguchi
  • View Affiliations

  • Published online on: January 1, 2006     https://doi.org/10.3892/ijmm.17.1.15
  • Pages: 15-20
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Abstract

The effect of β-cryptoxanthin, a kind of carotenoid, on ovariectomy-induced bone loss was investigated. β-cryptoxanthin was isolated from Satsuma mandarin (Citrus unshu. MARC). β-cryptoxanthin (5 or 10 µg/100 g body weight) was orally administered once daily for 3 months to ovariectomized (OVX) rats. OVX induced a significant increase in body weight and a significant decrease in serum calcium and inorganic phosphorus concentrations as compared with those of sham-operated (control) rats. These alterations induced by OVX were significantly prevented by the administration of β-cryptoxanthin (5 or 10 µg/100 g). The analysis using a peripheral quantitative computed tomography (pQCT) showed that OVX induced a significant decrease in mineral content and mineral density in the femoral-diaphyseal and -metaphyseal tissues and polar strength strain index in the metaphyseal tissues. These decreases were significantly prevented by the administration of β-cryptoxanthin (5 or 10 µg/100 g). Moreover, OVX induced a significant decrease in calcium content and alkaline phosphatase activity in the femoral-diaphyseal and -metaphyseal tissues and deoxyribonucleic acid (DNA) content in the metaphyseal tissues. These decreases were significantly prevented by the administration of β-cryptoxanthin (5 or 10 µg/100 g). This study demonstrates that β-cryptoxanthin has a preventive effect on OVX-induced bone loss in vivo.

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January 2006
Volume 17 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Uchiyama S and Uchiyama S: Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats. Int J Mol Med 17: 15-20, 2006
APA
Uchiyama, S., & Uchiyama, S. (2006). Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats. International Journal of Molecular Medicine, 17, 15-20. https://doi.org/10.3892/ijmm.17.1.15
MLA
Uchiyama, S., Yamaguchi, M."Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats". International Journal of Molecular Medicine 17.1 (2006): 15-20.
Chicago
Uchiyama, S., Yamaguchi, M."Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats". International Journal of Molecular Medicine 17, no. 1 (2006): 15-20. https://doi.org/10.3892/ijmm.17.1.15