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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2006 Volume 17 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2006 Volume 17 Issue 1

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Article

Induction of apoptosis on carcinoma cells by two synthetic cantharidin analogues

  • Authors:
    • Stanton Hon Lung Kok
    • Chung Hin Chui
    • Wing Sze Lam
    • Jien Chen
    • Johnny Cheuk On Tang
    • Fung Yi Lau
    • Gregory Yin Ming Cheng
    • Raymond Siu Ming Wong
    • Albert Sun Chi Chan

  • View Affiliations / Copyright

    Affiliations: Anti-cancer Research Center, Shenzhen Key Laboratory of Chinese Medicine and Molecular Pharmacology and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China
  • Pages: 151-157
    |
    Published online on: January 1, 2006
       https://doi.org/10.3892/ijmm.17.1.151
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Abstract

Cantharidin isolated from Mylabris caraganae and other insects has been used as an anti-cancer drug in China for many years. However, its toxicity on the renal system and suppression effect on bone marrow limits its usage clinically. Based on the core structure of cantharidin, we have chemically synthesized two cantharidin analogues (compounds 2 and 3). The cytotoxic activity of these analogues was demonstrated on the Hep3B hepatocellular carcinoma, MDA-MB231 breast cancer, A549 non-small cell lung carcinoma and KG1a acute myelogenous leukaemia (AML) cell lines by monitoring the intracellular adenosine triphosphate level. Morphological changes in these cancer cell lines, including cell shrinkage and loss of adherent potential, were readily observed. By making use of the KG1a AML cells as a test model, we further found that mitochondrial membrane potential depolarization and reduction of intracellular bcl-2 anti-apoptotic protein level were involved. These resulted in the activation of caspase 3 protease activity and oligonucleosomal length DNA fragment formation as detected by both time resolved fluorescence technology-based caspase activity assay and TdT-mediated dUTP nick end-labelling assay.

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Copy and paste a formatted citation
Spandidos Publications style
Kok SH, Chui CH, Lam WS, Chen J, Tang JC, Lau FY, Cheng GY, Wong RS and Chan AS: Induction of apoptosis on carcinoma cells by two synthetic cantharidin analogues. Int J Mol Med 17: 151-157, 2006.
APA
Kok, S.H., Chui, C.H., Lam, W.S., Chen, J., Tang, J.C., Lau, F.Y. ... Chan, A.S. (2006). Induction of apoptosis on carcinoma cells by two synthetic cantharidin analogues. International Journal of Molecular Medicine, 17, 151-157. https://doi.org/10.3892/ijmm.17.1.151
MLA
Kok, S. H., Chui, C. H., Lam, W. S., Chen, J., Tang, J. C., Lau, F. Y., Cheng, G. Y., Wong, R. S., Chan, A. S."Induction of apoptosis on carcinoma cells by two synthetic cantharidin analogues". International Journal of Molecular Medicine 17.1 (2006): 151-157.
Chicago
Kok, S. H., Chui, C. H., Lam, W. S., Chen, J., Tang, J. C., Lau, F. Y., Cheng, G. Y., Wong, R. S., Chan, A. S."Induction of apoptosis on carcinoma cells by two synthetic cantharidin analogues". International Journal of Molecular Medicine 17, no. 1 (2006): 151-157. https://doi.org/10.3892/ijmm.17.1.151
Copy and paste a formatted citation
x
Spandidos Publications style
Kok SH, Chui CH, Lam WS, Chen J, Tang JC, Lau FY, Cheng GY, Wong RS and Chan AS: Induction of apoptosis on carcinoma cells by two synthetic cantharidin analogues. Int J Mol Med 17: 151-157, 2006.
APA
Kok, S.H., Chui, C.H., Lam, W.S., Chen, J., Tang, J.C., Lau, F.Y. ... Chan, A.S. (2006). Induction of apoptosis on carcinoma cells by two synthetic cantharidin analogues. International Journal of Molecular Medicine, 17, 151-157. https://doi.org/10.3892/ijmm.17.1.151
MLA
Kok, S. H., Chui, C. H., Lam, W. S., Chen, J., Tang, J. C., Lau, F. Y., Cheng, G. Y., Wong, R. S., Chan, A. S."Induction of apoptosis on carcinoma cells by two synthetic cantharidin analogues". International Journal of Molecular Medicine 17.1 (2006): 151-157.
Chicago
Kok, S. H., Chui, C. H., Lam, W. S., Chen, J., Tang, J. C., Lau, F. Y., Cheng, G. Y., Wong, R. S., Chan, A. S."Induction of apoptosis on carcinoma cells by two synthetic cantharidin analogues". International Journal of Molecular Medicine 17, no. 1 (2006): 151-157. https://doi.org/10.3892/ijmm.17.1.151
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