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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2006 Volume 17 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2006 Volume 17 Issue 1

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Article

Expression of β-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells

  • Authors:
    • Jolana Turecková
    • Dana Kucerová
    • Martina Vojtechová
    • Eva Sloncová
    • Zdena Tuhácková

  • View Affiliations / Copyright

    Affiliations: Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 166 37 Prague 6, Czech Republic. turejo@img.cas.cz
  • Pages: 69-75
    |
    Published online on: January 1, 2006
       https://doi.org/10.3892/ijmm.17.1.69
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Abstract

β-catenin has a dual function; it is implicated in intercellular junctions and transcriptional co-activation. Here we examined the regulation of the expression and localization of β-catenin in HT29 colorectal adenocarcinoma cells. Our results showed that inhibition of PI-3 kinase with wortmannin was accompanied by a considerably reduced expression of β-catenin. This effect was overcome by butyrate and occured at the protein level, not at the level of mRNA. Moreover, NaBT significantly increased the phosphorylation of the ribosomal protein, S6, known to participate in the translational control of gene expression. This was accompanied by the increased phosphorylation of p70 S6K and MAPKs, the effector proteins that are upstream of protein S6 in the distinct signaling pathways. These facts indicate that different signaling pathways may be involved in the regulation of β-catenin synthesis. Modulation of β-catenin expression induced by NaBT appeared to occur at the level of protein translation, suggesting that NaBT may act as a translational regulator.

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Copy and paste a formatted citation
Spandidos Publications style
Turecková J, Kucerová D, Vojtechová M, Sloncová E and Tuhácková Z: Expression of β-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells. Int J Mol Med 17: 69-75, 2006.
APA
Turecková, J., Kucerová, D., Vojtechová, M., Sloncová, E., & Tuhácková, Z. (2006). Expression of β-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells. International Journal of Molecular Medicine, 17, 69-75. https://doi.org/10.3892/ijmm.17.1.69
MLA
Turecková, J., Kucerová, D., Vojtechová, M., Sloncová, E., Tuhácková, Z."Expression of β-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells". International Journal of Molecular Medicine 17.1 (2006): 69-75.
Chicago
Turecková, J., Kucerová, D., Vojtechová, M., Sloncová, E., Tuhácková, Z."Expression of β-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells". International Journal of Molecular Medicine 17, no. 1 (2006): 69-75. https://doi.org/10.3892/ijmm.17.1.69
Copy and paste a formatted citation
x
Spandidos Publications style
Turecková J, Kucerová D, Vojtechová M, Sloncová E and Tuhácková Z: Expression of β-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells. Int J Mol Med 17: 69-75, 2006.
APA
Turecková, J., Kucerová, D., Vojtechová, M., Sloncová, E., & Tuhácková, Z. (2006). Expression of β-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells. International Journal of Molecular Medicine, 17, 69-75. https://doi.org/10.3892/ijmm.17.1.69
MLA
Turecková, J., Kucerová, D., Vojtechová, M., Sloncová, E., Tuhácková, Z."Expression of β-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells". International Journal of Molecular Medicine 17.1 (2006): 69-75.
Chicago
Turecková, J., Kucerová, D., Vojtechová, M., Sloncová, E., Tuhácková, Z."Expression of β-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells". International Journal of Molecular Medicine 17, no. 1 (2006): 69-75. https://doi.org/10.3892/ijmm.17.1.69
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