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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2006 Volume 18 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2006 Volume 18 Issue 2

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Article

Curcumin inhibits telomerase activity in human cancer cell lines

  • Authors:
    • Shu-Xiang Cui
    • Xian-Jun Qu
    • Yan-Ying Xie
    • Ling Zhou
    • Munehiro Nakata
    • Masatoshi Makuuchi
    • Wei Tang

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, Shandong, P.R. China
  • Pages: 227-231
    |
    Published online on: August 1, 2006
       https://doi.org/10.3892/ijmm.18.2.227
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Abstract

Curcumin, one of the major components of tumeric, the dried rhizome of Curcuma longa L, has been shown to have anti-proliferating and anti-carcinogenic properties. In this study, we examined the effects of curcumin on cell growth and telomerase activity in human cancer cell lines Bel7402, HL60 and SGC7901. Curcumin (1-32 µM) showed anti-proliferating effects on these cell lines in a dose-dependent manner in vitro, and anti-tumor effects when curcumin (50-200 mg/kg) was orally administered to nude mice transplanted with the cancer cells. When the cells were treated with 1 µM of curcumin for 120 h, apoptotic cells were observed by means of the adridine orange/ethidium bromide staining method, single cell microgel electrophoresis and flow cytometric analysis. On the other hand, suppression of telomerase activity in extracts of the cells treated with 1 µM of curcumin was observed by means of a telomeric repeat amplification protocol - silver staining assay. These results suggest that curcumin could suppress telomerase activity in the cancer cell lines and that the decrease of telomerase expression followed by induction of apoptosis might be involved in the anti-proliferating effect of curcumin.

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Copy and paste a formatted citation
Spandidos Publications style
Cui S, Qu X, Xie Y, Zhou L, Nakata M, Makuuchi M and Tang W: Curcumin inhibits telomerase activity in human cancer cell lines. Int J Mol Med 18: 227-231, 2006.
APA
Cui, S., Qu, X., Xie, Y., Zhou, L., Nakata, M., Makuuchi, M., & Tang, W. (2006). Curcumin inhibits telomerase activity in human cancer cell lines. International Journal of Molecular Medicine, 18, 227-231. https://doi.org/10.3892/ijmm.18.2.227
MLA
Cui, S., Qu, X., Xie, Y., Zhou, L., Nakata, M., Makuuchi, M., Tang, W."Curcumin inhibits telomerase activity in human cancer cell lines". International Journal of Molecular Medicine 18.2 (2006): 227-231.
Chicago
Cui, S., Qu, X., Xie, Y., Zhou, L., Nakata, M., Makuuchi, M., Tang, W."Curcumin inhibits telomerase activity in human cancer cell lines". International Journal of Molecular Medicine 18, no. 2 (2006): 227-231. https://doi.org/10.3892/ijmm.18.2.227
Copy and paste a formatted citation
x
Spandidos Publications style
Cui S, Qu X, Xie Y, Zhou L, Nakata M, Makuuchi M and Tang W: Curcumin inhibits telomerase activity in human cancer cell lines. Int J Mol Med 18: 227-231, 2006.
APA
Cui, S., Qu, X., Xie, Y., Zhou, L., Nakata, M., Makuuchi, M., & Tang, W. (2006). Curcumin inhibits telomerase activity in human cancer cell lines. International Journal of Molecular Medicine, 18, 227-231. https://doi.org/10.3892/ijmm.18.2.227
MLA
Cui, S., Qu, X., Xie, Y., Zhou, L., Nakata, M., Makuuchi, M., Tang, W."Curcumin inhibits telomerase activity in human cancer cell lines". International Journal of Molecular Medicine 18.2 (2006): 227-231.
Chicago
Cui, S., Qu, X., Xie, Y., Zhou, L., Nakata, M., Makuuchi, M., Tang, W."Curcumin inhibits telomerase activity in human cancer cell lines". International Journal of Molecular Medicine 18, no. 2 (2006): 227-231. https://doi.org/10.3892/ijmm.18.2.227
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