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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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September 2006 Volume 18 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2006 Volume 18 Issue 3

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Article

Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts

  • Authors:
    • Osamu Inatomi
    • Akira Andoh
    • Yuhki Yagi
    • Shigeki Bamba
    • Tomoyuki Tsujikawa
    • Yoshihide Fujiyama

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Shiga University of Medical Science, Otsu 520-2192, Japan
  • Pages: 497-503
    |
    Published online on: September 1, 2006
       https://doi.org/10.3892/ijmm.18.3.497
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Abstract

Amphiregulin and epiregulin belong to the epidermal growth factor (EGF) family, and act as mitogenic stimulators via binding to EGF receptors (EGFRs). Amphiregulin and epiregulin are thought to play a role in regenerative responses in the gastrointestinal tract. In this study, we investigated secretion of amphiregulin and epiregulin in human colonic subepithelial myofibroblasts (SEMFs). The mRNA expression and protein secretion of amphiregulin and epiregulin were evaluated by Northern blotting and Western blotting, respectively. The trophic effects of amphiregulin and epiregulin on SEMFs were analyzed by MTT assays. Amphiregulin and epiregulin mRNAs were not detected in unstimulated SEMFs. Among the various cytokines and growth factors, interleukin-1β, tumor necrosis factor-α, and EGF strongly induced amphiregulin and epiregulin mRNA expression. These responses were markedly reduced by AG1478, a specific inhibitor of EGF receptor tyrosine kinases. Amphiregulin and epiregulin secretion were also detected at the protein level. MTT assays demonstrated that amphiregulin and epiregulin stimulate the proliferation of SEMFs. We demonstrated expression of amphiregulin and epiregulin in SEMFs. Amphiregulin and epiregulin may play an important role in the mechanism underlying wound healing in damaged colonic mucosa.

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Copy and paste a formatted citation
Spandidos Publications style
Inatomi O, Andoh A, Yagi Y, Bamba S, Tsujikawa T and Fujiyama Y: Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts. Int J Mol Med 18: 497-503, 2006.
APA
Inatomi, O., Andoh, A., Yagi, Y., Bamba, S., Tsujikawa, T., & Fujiyama, Y. (2006). Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts. International Journal of Molecular Medicine, 18, 497-503. https://doi.org/10.3892/ijmm.18.3.497
MLA
Inatomi, O., Andoh, A., Yagi, Y., Bamba, S., Tsujikawa, T., Fujiyama, Y."Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts". International Journal of Molecular Medicine 18.3 (2006): 497-503.
Chicago
Inatomi, O., Andoh, A., Yagi, Y., Bamba, S., Tsujikawa, T., Fujiyama, Y."Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts". International Journal of Molecular Medicine 18, no. 3 (2006): 497-503. https://doi.org/10.3892/ijmm.18.3.497
Copy and paste a formatted citation
x
Spandidos Publications style
Inatomi O, Andoh A, Yagi Y, Bamba S, Tsujikawa T and Fujiyama Y: Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts. Int J Mol Med 18: 497-503, 2006.
APA
Inatomi, O., Andoh, A., Yagi, Y., Bamba, S., Tsujikawa, T., & Fujiyama, Y. (2006). Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts. International Journal of Molecular Medicine, 18, 497-503. https://doi.org/10.3892/ijmm.18.3.497
MLA
Inatomi, O., Andoh, A., Yagi, Y., Bamba, S., Tsujikawa, T., Fujiyama, Y."Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts". International Journal of Molecular Medicine 18.3 (2006): 497-503.
Chicago
Inatomi, O., Andoh, A., Yagi, Y., Bamba, S., Tsujikawa, T., Fujiyama, Y."Regulation of amphiregulin and epiregulin expression in human colonic subepithelial myofibroblasts". International Journal of Molecular Medicine 18, no. 3 (2006): 497-503. https://doi.org/10.3892/ijmm.18.3.497
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