Pulmonary exposure to diesel exhaust particles enhances fatty change of the liver in obese diabetic mice

Tomaru,Makoto; Takano,Hirohisa; Inoue,Ken-Ichiro; Yanagisawa,Rie; Osakabe,Naomi; Yasuda,Akiko; Shimada,Akinori; Kato,Yoji; Uematsu,Hiroshi

doi:10.3892/ijmm.19.1.17

January 2007 Volume 19 Issue 1

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January 2007 Volume 19 Issue 1

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Article

Pulmonary exposure to diesel exhaust particles enhances fatty change of the liver in obese diabetic mice

Authors:
- Makoto Tomaru
- Hirohisa Takano
- Ken-Ichiro Inoue
- Rie Yanagisawa
- Naomi Osakabe
- Akiko Yasuda
- Akinori Shimada
- Yoji Kato
- Hiroshi Uematsu
View Affiliations / Copyright

Affiliations: Gerodontology, Department of Gerodontology, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Pages: 17-22
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Published online on: January 1, 2007

https://doi.org/10.3892/ijmm.19.1.17
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Abstract

In epidemiological studies, exposure to ambient particulate matter (PM) has been reported to be positively associated with mortality in subjects with diabetes mellitus. Diesel exhaust particles (DEP) are major constituents of atmospheric PM. However, there is no experimental evidence for the relation of DEP to diabetes mellitus and its complications. We investigated the effects of DEP inoculated intratracheally on diabetic changes and nonalcoholic fatty liver disease (NAFLD) in diabetic obese and control mice. db/db mice and the corresponding nondiabetic db/+m mice received exposure to vehicle or DEP every two weeks. Animals were examined with biochemistry, histology, and immunohistochemistry for hexanoyl-lysine (HEL) in the liver. In the db/+m mice, pulmonary exposure to DEP did not increase levels of aspartate aminotransferase (AST) or alanine aminotransferase (ALT) compared to that to vehicle. In the db/db mice, however, the exposure to DEP increased the levels of AST and ALT compared to that to vehicle. Only in the db/db mice, DEP enhanced the magnitude of steatosis and formation of HEL, a marker of oxidative stress, in the liver compared to vehicle. These results suggest that pulmonary exposure to DEP, PM, enhances steatosis in the liver of obese diabetic subjects possibly via enhanced oxidative stress.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pulmonary exposure to diesel exhaust particles enhances fatty change of the liver in obese diabetic mice

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Abstract

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