β amyloid angiogenic activity in vitro and in vivo

  • Authors:
    • Elisa Boscolo
    • Marcella Folin
    • Beatrice Nico
    • Claudio Grandi
    • Domenica Mangieri
    • Vito Longo
    • Renato Scienza
    • Paolo Zampieri
    • Maria Teresa Conconi
    • Pier Paolo Parnigotto
    • Domenico Ribatti
  • View Affiliations

  • Published online on: April 1, 2007     https://doi.org/10.3892/ijmm.19.4.581
  • Pages: 581-587
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Abstract

Angiogenesis has been suggested as a direct contributor to Alzheimer's disease (AD) pathology. The major pathological hallmarks of AD are the presence of neurofibrillary tangles and, β-amyloid plaques associated with activated microglia, astrocytes, degenerating neurons and vascular toxicity. In this study, Aβ1-40 and Aβ1-42 peptides, both components of the senile plaques in AD, were used to study their angiogenic activity in vitro, by using normal human cerebral endothelial cells (HCECs), and in vivo, by using the chick embryo chorioallantoic membrane (CAM) assay. Results showed that both peptides stimulate in vitro endothelial cell proliferation, chemotaxis and morphogenesis in Matrigel. Moreover, by using the aorta ring assay, both peptides stimulated the formation of capillary-like structures. An angiogenic response was induced in the CAM assay, similar to that induced by fibroblast growth factor-2 (FGF-2), a well-known angiogenic cytokine. Overall, these data support the hypothesis that Aβ peptides may contribute to angiogenesis occurring in AD and suggest that limiting the pro-angiogenic activity of Aβ peptides may therefore provide a useful target to control angiogenesis associated to AD and therefore limit the disease progression.

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April 2007
Volume 19 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Boscolo E, Folin M, Nico B, Grandi C, Mangieri D, Longo V, Scienza R, Zampieri P, Conconi MT, Parnigotto PP, Parnigotto PP, et al: β amyloid angiogenic activity in vitro and in vivo. Int J Mol Med 19: 581-587, 2007
APA
Boscolo, E., Folin, M., Nico, B., Grandi, C., Mangieri, D., Longo, V. ... Ribatti, D. (2007). β amyloid angiogenic activity in vitro and in vivo. International Journal of Molecular Medicine, 19, 581-587. https://doi.org/10.3892/ijmm.19.4.581
MLA
Boscolo, E., Folin, M., Nico, B., Grandi, C., Mangieri, D., Longo, V., Scienza, R., Zampieri, P., Conconi, M. T., Parnigotto, P. P., Ribatti, D."β amyloid angiogenic activity in vitro and in vivo". International Journal of Molecular Medicine 19.4 (2007): 581-587.
Chicago
Boscolo, E., Folin, M., Nico, B., Grandi, C., Mangieri, D., Longo, V., Scienza, R., Zampieri, P., Conconi, M. T., Parnigotto, P. P., Ribatti, D."β amyloid angiogenic activity in vitro and in vivo". International Journal of Molecular Medicine 19, no. 4 (2007): 581-587. https://doi.org/10.3892/ijmm.19.4.581