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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2007 Volume 19 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2007 Volume 19 Issue 5

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Review

Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review)

  • Authors:
    • Ponniah Selvakumar
    • Rajendra K. Sharma
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Laboratory Medicine, College of Medicine and Health Research Division, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatchewan S7N 4H4, Canada
  • Pages: 823-827
    |
    Published online on: May 1, 2007
       https://doi.org/10.3892/ijmm.19.5.823
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Abstract

A number of viral and eukaryotic proteins which undergo a lipophilic modification by the enzyme N-myristoyltransferase (NMT: NMT1 and NMT2) are required for signal transduction and regulatory functions. We reported a higher expression of NMT2 in most of the cases of cancerous tissues compared to normal tissues by Western blot analysis. Furthermore, protein-protein interaction of NMTs revealed that m-calpain interacts with NMT1 while caspase-3 interacts with NMT2. Our findings provide the first evidence of higher expression of NMT2 in human colorectal adenocarcinomas and the interaction of both forms of NMT with various signaling molecules. In this review, we summarize the recent findings on NMT2 in human colon cancer in our laboratory.

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Copy and paste a formatted citation
Spandidos Publications style
Selvakumar P and Sharma RK: Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review). Int J Mol Med 19: 823-827, 2007.
APA
Selvakumar, P., & Sharma, R.K. (2007). Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review). International Journal of Molecular Medicine, 19, 823-827. https://doi.org/10.3892/ijmm.19.5.823
MLA
Selvakumar, P., Sharma, R. K."Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review)". International Journal of Molecular Medicine 19.5 (2007): 823-827.
Chicago
Selvakumar, P., Sharma, R. K."Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review)". International Journal of Molecular Medicine 19, no. 5 (2007): 823-827. https://doi.org/10.3892/ijmm.19.5.823
Copy and paste a formatted citation
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Spandidos Publications style
Selvakumar P and Sharma RK: Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review). Int J Mol Med 19: 823-827, 2007.
APA
Selvakumar, P., & Sharma, R.K. (2007). Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review). International Journal of Molecular Medicine, 19, 823-827. https://doi.org/10.3892/ijmm.19.5.823
MLA
Selvakumar, P., Sharma, R. K."Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review)". International Journal of Molecular Medicine 19.5 (2007): 823-827.
Chicago
Selvakumar, P., Sharma, R. K."Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review)". International Journal of Molecular Medicine 19, no. 5 (2007): 823-827. https://doi.org/10.3892/ijmm.19.5.823
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