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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2007 Volume 19 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2007 Volume 19 Issue 6

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Article

SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells

  • Authors:
    • Takuya Uehara
    • Kenji Suzuki
    • Hideyuki Yamanaka
    • Takako Kizaki
    • Takuya Sakurai
    • Yoshinaga Ishibashi
    • Hitoshi Ishida
    • Hideki Ohno

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Medicinal Sciences, Department of Bioscience and Bioinformatics, College of Information Science and Engineering, Ritsumeikan University, Shiga 525-8577, Japan
  • Pages: 895-900
    |
    Published online on: June 1, 2007
       https://doi.org/10.3892/ijmm.19.6.895
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Abstract

The Src homology domain 2 (SH2)-containing tyrosine phosphatase SHP-2 has been implicated in the regulation of proliferation and differentiation in various cell types. Here, we investigated the ability of SHP-2 to mediate insulin-induced adipogenic differentiation of mouse 3T3-L1 cells. We found that the expression of SHP-2 was increased along with adipogenic differentiation. Overexpression of wild-type SHP-2 in 3T3-L1 cells resulted in enhanced adipocyte differentiation. Furthermore, insulin-stimulated adipogenic differentiation of 3T3-L1 cells was abolished by down-regulating SHP-2 expression using short interfering RNA. These results suggest that SHP-2 is a positive effector in signal transduction pathways necessary for adipocyte differentiation. In SHP-2 knockdown cells, the expression of peroxisome proliferator-activated receptor γ, a master regulator of adipogenesis, was entirely suppressed even in the late phase of differentiation, whereas the expression level of C/EBPδ was unchanged. These results highlight a novel role of SHP-2 in the signal transduction pathways regulating adipocyte differentiation.

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Copy and paste a formatted citation
Spandidos Publications style
Uehara T, Suzuki K, Yamanaka H, Kizaki T, Sakurai T, Ishibashi Y, Ishida H and Ohno H: SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells. Int J Mol Med 19: 895-900, 2007.
APA
Uehara, T., Suzuki, K., Yamanaka, H., Kizaki, T., Sakurai, T., Ishibashi, Y. ... Ohno, H. (2007). SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells. International Journal of Molecular Medicine, 19, 895-900. https://doi.org/10.3892/ijmm.19.6.895
MLA
Uehara, T., Suzuki, K., Yamanaka, H., Kizaki, T., Sakurai, T., Ishibashi, Y., Ishida, H., Ohno, H."SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells". International Journal of Molecular Medicine 19.6 (2007): 895-900.
Chicago
Uehara, T., Suzuki, K., Yamanaka, H., Kizaki, T., Sakurai, T., Ishibashi, Y., Ishida, H., Ohno, H."SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells". International Journal of Molecular Medicine 19, no. 6 (2007): 895-900. https://doi.org/10.3892/ijmm.19.6.895
Copy and paste a formatted citation
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Spandidos Publications style
Uehara T, Suzuki K, Yamanaka H, Kizaki T, Sakurai T, Ishibashi Y, Ishida H and Ohno H: SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells. Int J Mol Med 19: 895-900, 2007.
APA
Uehara, T., Suzuki, K., Yamanaka, H., Kizaki, T., Sakurai, T., Ishibashi, Y. ... Ohno, H. (2007). SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells. International Journal of Molecular Medicine, 19, 895-900. https://doi.org/10.3892/ijmm.19.6.895
MLA
Uehara, T., Suzuki, K., Yamanaka, H., Kizaki, T., Sakurai, T., Ishibashi, Y., Ishida, H., Ohno, H."SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells". International Journal of Molecular Medicine 19.6 (2007): 895-900.
Chicago
Uehara, T., Suzuki, K., Yamanaka, H., Kizaki, T., Sakurai, T., Ishibashi, Y., Ishida, H., Ohno, H."SHP-2 positively regulates adipogenic differentiation in 3T3-L1 cells". International Journal of Molecular Medicine 19, no. 6 (2007): 895-900. https://doi.org/10.3892/ijmm.19.6.895
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