search button

Spontaneous murine lung adenocarcinoma (P07): A new experimental model to study paraneoplastic syndromes of lung cancer.

  • Authors:
    • M J Diament
    • C Garcìa
    • I Stillitani
    • V M Saavedra
    • T Manzur
    • L Vauthay
    • S Klein

  • View Affiliations

  • Published online on: July 1, 1998     https://doi.org/10.3892/ijmm.2.1.45
  • Pages: 45-95
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We report the histological and biological behavior characteristics of a lung tumor (P07) that arose spontaneously in a Balb/c mouse. P07 is a moderately to poorly differentiated adenocarcinoma that secretes granulocyte-macrophage colony stimulating factor (GM-CSF) in culture supernatants. This tumor presents some paraneoplastic syndromes, such as leukocytosis, hypercalcemia and cachexia. taken together with the peripheral blood leukocyte (PBL) counts and serum calcium levels during s.c. tumor growth and after surgery, this study suggests that P07 may be a useful experimental model to study the biology of lung cancer and paraneoplastic syndromes.

Related Articles

Journal Cover

Jul 1998
Volume 2 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Diament M, Garcìa C, Stillitani I, Saavedra V, Manzur T, Vauthay L and Klein S: Spontaneous murine lung adenocarcinoma (P07): A new experimental model to study paraneoplastic syndromes of lung cancer.. Int J Mol Med 2: 45-95, 1998
APA
Diament, M., Garcìa, C., Stillitani, I., Saavedra, V., Manzur, T., Vauthay, L., & Klein, S. (1998). Spontaneous murine lung adenocarcinoma (P07): A new experimental model to study paraneoplastic syndromes of lung cancer.. International Journal of Molecular Medicine, 2, 45-95. https://doi.org/10.3892/ijmm.2.1.45
MLA
Diament, M., Garcìa, C., Stillitani, I., Saavedra, V., Manzur, T., Vauthay, L., Klein, S."Spontaneous murine lung adenocarcinoma (P07): A new experimental model to study paraneoplastic syndromes of lung cancer.". International Journal of Molecular Medicine 2.1 (1998): 45-95.
Chicago
Diament, M., Garcìa, C., Stillitani, I., Saavedra, V., Manzur, T., Vauthay, L., Klein, S."Spontaneous murine lung adenocarcinoma (P07): A new experimental model to study paraneoplastic syndromes of lung cancer.". International Journal of Molecular Medicine 2, no. 1 (1998): 45-95. https://doi.org/10.3892/ijmm.2.1.45