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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2007 Volume 20 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes

  • Authors:
    • Toshiaki Takahashi
    • Elisabeth A. Morris
    • Stephen B. Trippel

  • View Affiliations / Copyright

    Affiliations: Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan. takahast@m.ehime-u.ac.jp
  • Pages: 53-57
    |
    Published online on: July 1, 2007
       https://doi.org/10.3892/ijmm.20.1.53
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Abstract

Insulin-like growth factor-I (IGF-I) is thought to play an important role in skeletal growth and development through its mitogenic and anabolic effects on epiphyseal growth plate chondrocytes. The bone morphogenetic proteins (BMPs) have been shown to promote endochondral osteogenesis, and some members of the BMP family, including BMP-2 and BMP-9, have anabolic effects on chondrocyte metabolism. We tested the hypothesis that BMP-2 and BMP-9 interact with IGF-I to modulate growth plate chondrocyte mitotic activity. IGF-I, but neither BMP-2 nor BMP-9, stimulated chondrocyte DNA synthesis. However, both BMP-2 and BMP-9 augmented the mitogenic action of IGF-I. BMP-2, but not BMP-9 increased IGF-I binding to growth plate chondrocytes in kinetic studies. In affinity labeling studies, 125I-IGF-I predominantly labeled an Mr ≈135-kDa moiety, consistent with the α subunit of the type 1 IGF receptor and an Mr ≈250-kDa moiety consistent with the type 2 IGF receptor. 125I-IGF-I labeling also appeared at Mr ≈43 kDa, consistent with 125I-IGF-I binding to insulin-like growth binding protein-3. Treatment of chondrocytes with BMP-2, but not with BMP-9, increased the intensity of the Mr ≈135-kDa band and decreased the intensity of the Mr ≈43-kDa band. Taken together, these data suggest that the BMPs may modulate the action of IGF-I via the type 1 IGF receptor and/or IGF binding proteins.

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Copy and paste a formatted citation
Spandidos Publications style
Takahashi T, Morris EA and Trippel SB: Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes. Int J Mol Med 20: 53-57, 2007.
APA
Takahashi, T., Morris, E.A., & Trippel, S.B. (2007). Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes. International Journal of Molecular Medicine, 20, 53-57. https://doi.org/10.3892/ijmm.20.1.53
MLA
Takahashi, T., Morris, E. A., Trippel, S. B."Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes". International Journal of Molecular Medicine 20.1 (2007): 53-57.
Chicago
Takahashi, T., Morris, E. A., Trippel, S. B."Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes". International Journal of Molecular Medicine 20, no. 1 (2007): 53-57. https://doi.org/10.3892/ijmm.20.1.53
Copy and paste a formatted citation
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Spandidos Publications style
Takahashi T, Morris EA and Trippel SB: Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes. Int J Mol Med 20: 53-57, 2007.
APA
Takahashi, T., Morris, E.A., & Trippel, S.B. (2007). Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes. International Journal of Molecular Medicine, 20, 53-57. https://doi.org/10.3892/ijmm.20.1.53
MLA
Takahashi, T., Morris, E. A., Trippel, S. B."Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes". International Journal of Molecular Medicine 20.1 (2007): 53-57.
Chicago
Takahashi, T., Morris, E. A., Trippel, S. B."Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes". International Journal of Molecular Medicine 20, no. 1 (2007): 53-57. https://doi.org/10.3892/ijmm.20.1.53
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