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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2007 Volume 20 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2007 Volume 20 Issue 1

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Article

Diallyl disulfide accelerates adipogenesis in 3T3-L1 cells

  • Authors:
    • Ji-Hyun Lee
    • Kyung-Ah Kim
    • Kang-Beom Kwon
    • Eun-Kyung Kim
    • Young-Rae Lee
    • Mi-Young Song
    • Jeung-Hyun Koo
    • Sun-O Ka
    • Jin-Woo Park
    • Byung-Hyun Park

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University, Jeonju 561-756, Korea
  • Pages: 59-64
    |
    Published online on: July 1, 2007
       https://doi.org/10.3892/ijmm.20.1.59
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Abstract

Adipocyte differentiation is regulated by the sequential activation of transcription factors such as the CAAT/enhancer binding protein and peroxisome proliferator- activated receptor-γ (PPAR-γ). Several recent studies have shown that regulators of chromatin structure are also involved in adipocyte differentiation. Here we investigated the effects of diallyl disulfide (DADS), an oil-soluble sulfur compound found in processed garlic and an inhibitor of histone deacetylase (HDAC), on adipogenesis. Treatment with DADS accelerated terminal differentiation of 3T3-L1 cells into adipocytes as evidenced by Oil red O staining and cellular triglyceride assay results. Notably, the inhibition of HDAC during the first 2 days was sufficient to stimulate adipogenesis. Western blot analysis revealed that DADS increased the level of acetylated histones H3 and H4. In addition, DADS increased the expression of adipogenesis-related genes; LPL, FAS, SREBP1c, aP2 and PPAR-γ, and decreased the expression of pref-1, a preadipocyte marker gene. Taken together, our results suggest that DADS affects adipocyte differentiation through histone acetylation at an early phase of adipocyte differentiation.

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Copy and paste a formatted citation
Spandidos Publications style
Lee J, Kim K, Kwon K, Kim E, Lee Y, Song M, Koo J, Ka S, Park J, Park B, Park B, et al: Diallyl disulfide accelerates adipogenesis in 3T3-L1 cells. Int J Mol Med 20: 59-64, 2007.
APA
Lee, J., Kim, K., Kwon, K., Kim, E., Lee, Y., Song, M. ... Park, B. (2007). Diallyl disulfide accelerates adipogenesis in 3T3-L1 cells. International Journal of Molecular Medicine, 20, 59-64. https://doi.org/10.3892/ijmm.20.1.59
MLA
Lee, J., Kim, K., Kwon, K., Kim, E., Lee, Y., Song, M., Koo, J., Ka, S., Park, J., Park, B."Diallyl disulfide accelerates adipogenesis in 3T3-L1 cells". International Journal of Molecular Medicine 20.1 (2007): 59-64.
Chicago
Lee, J., Kim, K., Kwon, K., Kim, E., Lee, Y., Song, M., Koo, J., Ka, S., Park, J., Park, B."Diallyl disulfide accelerates adipogenesis in 3T3-L1 cells". International Journal of Molecular Medicine 20, no. 1 (2007): 59-64. https://doi.org/10.3892/ijmm.20.1.59
Copy and paste a formatted citation
x
Spandidos Publications style
Lee J, Kim K, Kwon K, Kim E, Lee Y, Song M, Koo J, Ka S, Park J, Park B, Park B, et al: Diallyl disulfide accelerates adipogenesis in 3T3-L1 cells. Int J Mol Med 20: 59-64, 2007.
APA
Lee, J., Kim, K., Kwon, K., Kim, E., Lee, Y., Song, M. ... Park, B. (2007). Diallyl disulfide accelerates adipogenesis in 3T3-L1 cells. International Journal of Molecular Medicine, 20, 59-64. https://doi.org/10.3892/ijmm.20.1.59
MLA
Lee, J., Kim, K., Kwon, K., Kim, E., Lee, Y., Song, M., Koo, J., Ka, S., Park, J., Park, B."Diallyl disulfide accelerates adipogenesis in 3T3-L1 cells". International Journal of Molecular Medicine 20.1 (2007): 59-64.
Chicago
Lee, J., Kim, K., Kwon, K., Kim, E., Lee, Y., Song, M., Koo, J., Ka, S., Park, J., Park, B."Diallyl disulfide accelerates adipogenesis in 3T3-L1 cells". International Journal of Molecular Medicine 20, no. 1 (2007): 59-64. https://doi.org/10.3892/ijmm.20.1.59
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