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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2007 Volume 20 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-β1 and ameliorates acute colitis in mice

  • Authors:
    • Ute Bank
    • Janine Tadje
    • Michael Täger
    • Carmen Wolke
    • Alicja Bukowska
    • Annelore Ittenson
    • Dirk Reinhold
    • Martin Helmuth
    • Siegfried Ansorge
    • Ann Shakespeare
    • Michael Vieth
    • Peter Malfertheiner
    • Michael Naumann
    • Uwe Lendeckel
  • View Affiliations / Copyright

    Affiliations: IMTM GmbH, D-39120 Magdeburg, Germany
  • Pages: 483-492
    |
    Published online on: October 1, 2007
       https://doi.org/10.3892/ijmm.20.4.483
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Abstract

Inhibitors of alanyl-aminopeptidase e.g. phebestin increase the expression of transforming growth factor (TGF)-β1 in mononuclear cells. We investigated whether phebestin also produced this effect in CD4+CD25+ T-cells and whether phebestin-treated CD4+CD25+ T-cells were capable of ameliorating acute colitis in mice. The suppressive activity of mouse CD4+CD25+ T-cells was assessed in vitro by co-culture with splenocytes. mRNA expression associated with the suppressive phenotype was determined in vitro and in vivo. The in vivo role of phebestin-exposed CD4+CD25+ T-cells was studied in sodium dextran sulfate-induced acute colitis in mice. The proliferation of activated effector T-cells or splenocytes in vitro was inversely correlated with the number of CD4+CD25+ T-cells. Phebestin pre-treatment substantially enhanced the suppressive activity of these cells and increased expression levels of TGF-β1 and FoxP3. Furthermore, transfer of CD4+CD25+ T-cells exposed to phebestin for a short time ex vivo significantly reduced the mouse colitis disease activity index. We conclude that aminopeptidase inhibitors support the suppressive activity as well as TGF-β1 and FoxP3 expression of natural regulatory T-cells.

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Copy and paste a formatted citation
Spandidos Publications style
Bank U, Tadje J, Täger M, Wolke C, Bukowska A, Ittenson A, Reinhold D, Helmuth M, Ansorge S, Shakespeare A, Shakespeare A, et al: Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-β1 and ameliorates acute colitis in mice. Int J Mol Med 20: 483-492, 2007.
APA
Bank, U., Tadje, J., Täger, M., Wolke, C., Bukowska, A., Ittenson, A. ... Lendeckel, U. (2007). Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-β1 and ameliorates acute colitis in mice. International Journal of Molecular Medicine, 20, 483-492. https://doi.org/10.3892/ijmm.20.4.483
MLA
Bank, U., Tadje, J., Täger, M., Wolke, C., Bukowska, A., Ittenson, A., Reinhold, D., Helmuth, M., Ansorge, S., Shakespeare, A., Vieth, M., Malfertheiner, P., Naumann, M., Lendeckel, U."Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-β1 and ameliorates acute colitis in mice". International Journal of Molecular Medicine 20.4 (2007): 483-492.
Chicago
Bank, U., Tadje, J., Täger, M., Wolke, C., Bukowska, A., Ittenson, A., Reinhold, D., Helmuth, M., Ansorge, S., Shakespeare, A., Vieth, M., Malfertheiner, P., Naumann, M., Lendeckel, U."Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-β1 and ameliorates acute colitis in mice". International Journal of Molecular Medicine 20, no. 4 (2007): 483-492. https://doi.org/10.3892/ijmm.20.4.483
Copy and paste a formatted citation
x
Spandidos Publications style
Bank U, Tadje J, Täger M, Wolke C, Bukowska A, Ittenson A, Reinhold D, Helmuth M, Ansorge S, Shakespeare A, Shakespeare A, et al: Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-β1 and ameliorates acute colitis in mice. Int J Mol Med 20: 483-492, 2007.
APA
Bank, U., Tadje, J., Täger, M., Wolke, C., Bukowska, A., Ittenson, A. ... Lendeckel, U. (2007). Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-β1 and ameliorates acute colitis in mice. International Journal of Molecular Medicine, 20, 483-492. https://doi.org/10.3892/ijmm.20.4.483
MLA
Bank, U., Tadje, J., Täger, M., Wolke, C., Bukowska, A., Ittenson, A., Reinhold, D., Helmuth, M., Ansorge, S., Shakespeare, A., Vieth, M., Malfertheiner, P., Naumann, M., Lendeckel, U."Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-β1 and ameliorates acute colitis in mice". International Journal of Molecular Medicine 20.4 (2007): 483-492.
Chicago
Bank, U., Tadje, J., Täger, M., Wolke, C., Bukowska, A., Ittenson, A., Reinhold, D., Helmuth, M., Ansorge, S., Shakespeare, A., Vieth, M., Malfertheiner, P., Naumann, M., Lendeckel, U."Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-β1 and ameliorates acute colitis in mice". International Journal of Molecular Medicine 20, no. 4 (2007): 483-492. https://doi.org/10.3892/ijmm.20.4.483
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