Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes

  • Authors:
    • Jeong-Yeh Yang
    • Jeung-Hyun Koo
    • Ha-Yong Yoon
    • Ju-Hyung Lee
    • Byung-Hyun Park
    • Jong-Suk Kim
    • Myung S. Chi
    • Jin-Woo Park
  • View Affiliations

  • Published online on: October 1, 2007     https://doi.org/10.3892/ijmm.20.4.527
  • Pages: 527-531
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Abstract

Hypertriglyceridemia is an independent risk factor of cardiovascular diseases. It is caused by the imbalance between hepatic triglyceride production and peripheral removal. Lipoprotein lipase (LPL) plays a central role in the removal of plasma triglyceride. During the screening of possible anti-dyslipidemic drugs, we observed that scopoletin (6-methoxy-7-hydroxycoumarin) significantly increased LPL activity in adipocytes. Scopoletin increased LPL activity in culture medium of 3T3-L1 adipocytes in dose- and time-dependent manners. It did not release LPL from the adipocyte membrane and, instead, increased the LPL mRNA level, suggesting transcriptional control. Scopoletin also partially reversed tumor necrosis factor-α-induced suppression of LPL activity. These results suggest the possible action of scopoletin as a facilitator of plasma triglyceride clearance.

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October 2007
Volume 20 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yang J, Koo J, Yoon H, Lee J, Park B, Kim J, Chi MS and Park J: Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes. Int J Mol Med 20: 527-531, 2007
APA
Yang, J., Koo, J., Yoon, H., Lee, J., Park, B., Kim, J. ... Park, J. (2007). Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes. International Journal of Molecular Medicine, 20, 527-531. https://doi.org/10.3892/ijmm.20.4.527
MLA
Yang, J., Koo, J., Yoon, H., Lee, J., Park, B., Kim, J., Chi, M. S., Park, J."Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes". International Journal of Molecular Medicine 20.4 (2007): 527-531.
Chicago
Yang, J., Koo, J., Yoon, H., Lee, J., Park, B., Kim, J., Chi, M. S., Park, J."Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes". International Journal of Molecular Medicine 20, no. 4 (2007): 527-531. https://doi.org/10.3892/ijmm.20.4.527