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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2007 Volume 20 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and chronic gastritis

  • Authors:
    • Tomiyasu Arisawa
    • Tomomitsu Tahara
    • Tomoyuki Shibata
    • Mitsuo Nagasaka
    • Masakatsu Nakamura
    • Yoshio Kamiya
    • Hiroshi Fujita
    • Masahiko Nakamura
    • Daisuke Yoshioka
    • Yuko Arima
    • Masaaki Okubo
    • Ichiro Hirata
    • Hiroshi Nakano

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake 470-1192, Japan. tarisawa@fujita-hu.ac.jp
  • Pages: 539-544
    |
    Published online on: October 1, 2007
       https://doi.org/10.3892/ijmm.20.4.539
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Abstract

Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator, which plays a pivotal role in inflammatory and immune diseases. We attempted to clarify associations of the functional polymorphisms of the MIF gene promoter with the development of chronic gastritis. The study was performed with 290 stocked DNAs from subjects with no evidence of gastric malignancy. We employed the PCR-SSCP method to detect gene polymorphisms. The severity of histological chronic gastritis in antral biopsy specimens was classified according to the updated Sydney system. Both the 7/7-CATT repeat at position -794 and the -173 C/C genotypes were significantly associated with a risk of developing severe gastric mucosal atrophy (OR, 9.69; 95% CI, 1.29-72.5; and OR, 4.60; 95% CI, 1.05-20.2, respectively). In subjects younger than 60 years old, the number of 7-CATT alleles was significantly correlated with both the activity and inflammation scores (p=0.0079 and 0.0080, respectively). Our results suggested that functional promoter polymorphisms of the MIF gene might be associated with the severity of gastric mucosal inflammation in younger subjects and with the subsequent development of mucosal atrophy.

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Copy and paste a formatted citation
Spandidos Publications style
Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, Fujita H, Nakamura M, Yoshioka D, Arima Y, Arima Y, et al: Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and chronic gastritis. Int J Mol Med 20: 539-544, 2007.
APA
Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y. ... Nakano, H. (2007). Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and chronic gastritis. International Journal of Molecular Medicine, 20, 539-544. https://doi.org/10.3892/ijmm.20.4.539
MLA
Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., Fujita, H., Nakamura, M., Yoshioka, D., Arima, Y., Okubo, M., Hirata, I., Nakano, H."Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and chronic gastritis". International Journal of Molecular Medicine 20.4 (2007): 539-544.
Chicago
Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., Fujita, H., Nakamura, M., Yoshioka, D., Arima, Y., Okubo, M., Hirata, I., Nakano, H."Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and chronic gastritis". International Journal of Molecular Medicine 20, no. 4 (2007): 539-544. https://doi.org/10.3892/ijmm.20.4.539
Copy and paste a formatted citation
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Spandidos Publications style
Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, Fujita H, Nakamura M, Yoshioka D, Arima Y, Arima Y, et al: Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and chronic gastritis. Int J Mol Med 20: 539-544, 2007.
APA
Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y. ... Nakano, H. (2007). Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and chronic gastritis. International Journal of Molecular Medicine, 20, 539-544. https://doi.org/10.3892/ijmm.20.4.539
MLA
Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., Fujita, H., Nakamura, M., Yoshioka, D., Arima, Y., Okubo, M., Hirata, I., Nakano, H."Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and chronic gastritis". International Journal of Molecular Medicine 20.4 (2007): 539-544.
Chicago
Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., Fujita, H., Nakamura, M., Yoshioka, D., Arima, Y., Okubo, M., Hirata, I., Nakano, H."Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and chronic gastritis". International Journal of Molecular Medicine 20, no. 4 (2007): 539-544. https://doi.org/10.3892/ijmm.20.4.539
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