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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2007 Volume 20 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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October 2007 Volume 20 Issue 4

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Article

High frequency of promoter methylation of the 14-3-3 σ and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder

  • Authors:
    • Ekkehard Kunze
    • Thilo Schlott

  • View Affiliations / Copyright

    Affiliations: Department of Osteopathology and Haematopathology, University of Göttingen, D-37099 Göttingen, Germany. ekunze@med.uni-goettingen.de
  • Pages: 557-563
    |
    Published online on: October 1, 2007
       https://doi.org/10.3892/ijmm.20.4.557
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Abstract

The molecular mechanisms underlying the histogenesis of nonurothelial carcinomas of the urinary bladder are not yet clearly understood. There is a growing body of evidence that, generally, epigenetic regulation mediated by methylation of normally unmethylated CpG islands at the 5' promoter regions of genes is involved in the modification of tumorigenesis. This prompted the current study to explore the methylation status of a broad panel of various genes implicated in cell differentiation and tumor suppression in 10 adenocarcinomas and 6 signet ring cell carcinomas of the bladder. Using methylation-specific PCR, we were able to detect a high frequency of promoter methylation of the 14-3-3 σ (100%) and CAGE-1 (80%) genes in adenocarcinomas, and in nearly all signet ring cell carcinomas. The SYK and hDAB2IP genes proved to be hypermethylated in only single cases, whereas the caveolin-1 gene failed to be hypermethylated in all cases. The present data suggest that promoter methylation of the 14-3-3 σ and CAGE-1 genes plays a crucial role during the phenotypical morphogenesis of vesical adenocarcinomas including signet ring cell carcinomas by an epigenetic mechanism.

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Copy and paste a formatted citation
Spandidos Publications style
Kunze E and Schlott T: High frequency of promoter methylation of the 14-3-3 σ and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder. Int J Mol Med 20: 557-563, 2007.
APA
Kunze, E., & Schlott, T. (2007). High frequency of promoter methylation of the 14-3-3 σ and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder. International Journal of Molecular Medicine, 20, 557-563. https://doi.org/10.3892/ijmm.20.4.557
MLA
Kunze, E., Schlott, T."High frequency of promoter methylation of the 14-3-3 σ and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder". International Journal of Molecular Medicine 20.4 (2007): 557-563.
Chicago
Kunze, E., Schlott, T."High frequency of promoter methylation of the 14-3-3 σ and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder". International Journal of Molecular Medicine 20, no. 4 (2007): 557-563. https://doi.org/10.3892/ijmm.20.4.557
Copy and paste a formatted citation
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Spandidos Publications style
Kunze E and Schlott T: High frequency of promoter methylation of the 14-3-3 σ and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder. Int J Mol Med 20: 557-563, 2007.
APA
Kunze, E., & Schlott, T. (2007). High frequency of promoter methylation of the 14-3-3 σ and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder. International Journal of Molecular Medicine, 20, 557-563. https://doi.org/10.3892/ijmm.20.4.557
MLA
Kunze, E., Schlott, T."High frequency of promoter methylation of the 14-3-3 σ and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder". International Journal of Molecular Medicine 20.4 (2007): 557-563.
Chicago
Kunze, E., Schlott, T."High frequency of promoter methylation of the 14-3-3 σ and CAGE-1 genes, but lack of hypermethylation of the caveolin-1 gene, in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder". International Journal of Molecular Medicine 20, no. 4 (2007): 557-563. https://doi.org/10.3892/ijmm.20.4.557
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